Renal tubular cell apoptosis is a significant component of obstruction-induced renal injury, and it results in a progressive loss in renal parenchymal mass during renal obstruction. Although IL-18 is an important mediator of inflammatory renal disease and renal fibrosis, its role in obstruction-induced renal tubular cell apoptosis remains unclear. To study this, male C57BL6 wild-type mice and C...

Infarction of the kidney is an uncommon condition that can result from obstruction or decrease of renal arterial flow. The diagnosis is often delayed because it can mimic many other pathologic states, including pyelonephritis, renal colic, acute abdomen, pancreatitis and more. A high index of suspicion is important for prompt diagnosis. We describe a 20-year-old man presented with abdominal and...

Renal transplantation is the treatment of choice for chronic kidney disease and has been shown to have better outcomes than dialysis in multiple studies.1 In the standard procedure, the donor renal artery and vein are anastomosed to the external iliac vessels of the recipient. In cases of an unusable vein, such as thrombosis of the iliac vein or inferior vena cava (IVC), renal transplantation b...

Complete anuria is an uncommon clinical presentation that is usually due to an obstructive (postrenal) cause. Less frequent aetiologies include catastrophic vascular compromise (prerenal), massive rhabdomyolysis or antiglomerular basement membrane disease (intrinsic renal). Two-dimensional ultrasonography is the initial imaging investigation of choice in these patients, as it is non-invasive, c...

We investigated the renal response to direct renal nerve stimulation, 2 weeks following reversal of 24-h unilateral (left) ureteric obstruction. Renal nerve stimulation caused a 13-15 % fall in renal blood flow, in 4 groups of anesthetized rats following ureteric obstruction (n=9) or a sham operation (n=7) both with (n=9) and without (n=7) treatment with the mixed ET(A/B) receptor antagonist, b...

We investigated the renal response to direct renal nerve stimulation, 2 weeks following reversal of 24-hr unilateral (left) ureteric obstruction. Renal nerve stimulation caused a 13-15% fall in renal blood flow, in 4 groups of anaesthetised rats following ureteric obstruction (n=9) or a sham operation (n=7) both with (n=9) and without (n=7) treatment with the mixed ETA/B receptor antagonist, bo...

Background: Variation in Renal restive index (RI) values measured using duplex Doppler ultrasonography has been shown to correlate with the degree of renal impairment in acute renal obstruction ,diabetic and hypertensive nephropathy patients. Aims and objectives: The primary objective of this study was to determine whether the intrarenal resistive index can be used as a predictor of progression...

the objective of this study was to determine the chronology of changes in blood pressure in renalhypertension induced by solid plexiglass clips in rats. saw blades with the thickness of 0.21-0.22 mm wereused to make clips sized 4 × 2 × 2 mm from a piece of 2-mm thick plexiglass. rats were subjected to shamoperation or left renal arterial clipping, and 1, 2, 3 and 4 weeks later blood pressure, a...