preparation of chitosan (cs) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low cs molecular weight (mw) was investigated in this study. diphtheria toxoid (dt) was used as a model antigen. the emulsion-solidification method was adopted for microencapsulation of dt.  in the first step, following the purification of semi-crude dt by the ion-exchan...

In a liquid-liquid interface bioreactor, fungal cells locate in a hydrophilic polyacrylonitrile microsphere layer on an aqueous-organic interface. In this article, effects of hydrophobicity of the interface on n-decane hydroxylation activity of Monilliera sp. NAP 00702 was examined. (-)-4-Decanol production was significantly enhanced to 132% by addition of polytetrafluoroethylene.

The present investigation involves formulation and evaluation of microspheres with Repaglinide as model drug for prolongation of drug release time. An attempt was made to prepare microspheres of Repaglinide by Quasi emulsion solvent diffusion technique, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into systemic circulation. The mic...

Biodegradable polyesters, such as the poly(lactic-co-glycolic acid) (PLGA), have been extensively used a polymer matrix for entrapping variety of active compounds. In this study, physicochemical phenomena that control mass transport mechanism hydrophilic compounds released from PLGA microspheres were identified. This study aims to produce and characterize loaded with metformin hydrochloride (MH...

This article introduced the work of ethylcellulose based polymeric microsphere loaded with nifedipine for reduction in frequency of administration with low solubility in aqueous medium and high rate of absorption in the stomach. The non-aqueous polymeric suspension was put dropwise into an aqueous medium containing polyvinyl alcohol as a surfactant for the synthesis of microsphere by solvent ev...

As cartilage tissue has limited repair capacities, tissue engineering has emerged as a promising alternative for cartilage repair. The scaffold is a primary component of the tissue engineerig design, yet little inormation exists regarding the effects of polymer and scaffold properties on tissue growth. In this study, we have developed a novel scaffold, PLG micro spheres, for use in cartilage ti...