in this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. the effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

Dental biofilm bacteria can bind calcium ions and release them during a pH drop, which could decrease the driving force for dental demineralization (i.e. hydroxyapatite dissolution) occurring at reduced pHs. However, the kinetics of this binding and release is not completely understood. Here we validated a method to evaluate the kinetics of calcium binding and release to/from Streptococcus muta...

the dual fuel engines at part loads inevitably suffer from lower thermal efficiency and higher carbon monoxide and unburned fuel emission. this work is carried out to investigate combustion characteristics of a dual fuel (dieselgas) engine at part loads, using a single zone combustion model with detailed chemical kinetics for combustion of natural gas fuel. the authors developed software in whi...

This paper describes a combined modeling and experimental approach for the design and development of a polymer device to provide local drug therapy to thermally ablated solid tumors. The polymer device, in the shape of cylindrical millirod, will be implanted via image-guided procedures into the center of the ablated tumor. Drug released from the millirod aims to eliminate residual cancer cells ...

In this present study an attempt has been made to evaluate glyceryl monostearate (GMS) as a rate retarding material to sustain the release ciprofloxacin hydrochloride from the matrix tablet. The solubility of ciprofloxacin hydrochloride was studied. The physical parameters of the prepared tablets were also evaluated. Release kinetics of ciprofloxacin hydrochloride from this sustained release ma...

The objective of this study was to develop a sustained release matrix tablet Metoprolol Succinate by cost saving and production efficient process. Among various tablet manufacturing process, direct compression is the simplest and cost saving process. Different trials were formulated and evaluated using different concentrations of directly compressible grade Kollidon SR as release retardant. The...

A numerical model has been developed to investigate the thermally triggered release kinetics for drug delivery using phase change material as shell of microcapsules. Biocompatible material n-Eicosane is used as demonstration. PCM shell of microcapsule will remain in solid form after the drug is taken, so the drug will be encapsulated by the shell, and will not be released until the target body ...