Glucose sensing in the brain has been proposed to be involved in regulating food intake, but the mechanism is not known. Glucose transporter type 2 (GLUT2)-null mice fail to control their food intake in response to glucose, suggesting a potential role for this transporter as a glucose sensor in the brain. Here we show that individuals with a genetic variation in GLUT2 (Thr110Ile) have a higher ...

Obesity is rapidly increasing and is of great public health concern worldwide. Although there have been remarkable developments in obesity research over the past 10 years, the molecular mechanism of obesity is still not completely understood. Body weight results from the balance between food intake and energy expenditure. Recent studies have found that hypothalamic AMP-activated protein kinase ...

BACKGROUND New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake. OBJECTIVES We investigated whether the recently reported obesity loci are associated with measures of abdominal adiposity and whether these variants aff...

Protein feeding is known to decrease hunger and subsequent food intake in animals and humans. It has also been suggested that glucose appearance into portal vein, as occurring during meal assimilation, may induce comparable effects. Here, we connect these previous observations by reporting that intestinal gluconeogenesis (i.e., de novo synthesis of glucose) is induced during the postabsorptive ...

Obesity is a major public health issue worldwide. Current pharmacological treatments are largely unsuccessful. Determining the complex pathways that regulate food intake may aid the development of new treatments. The hypothalamic-pituitary-thyroid (HPT) axis has well-known effects on energy expenditure, but its role in the regulation of food intake is less well characterised. Evidence suggests ...

objective(s):consumption of high-fat foods is one of the major causes of obesity. physical exercise is a strategy used to counteract obesity. the aim of this study was to investigate the effect of eight weeks endurance training and high-fat diet (hfd) on appetite-regulating hormones in rat plasma. materials and methods:twenty eight male wistar rats were randomly divided into four groups: contro...

With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide. Because ghrelin is increased by caloric restriction, ghrelin may play an important rol...

Examining a potential functional role for growth hormone secretagogue receptors in the hippocampus, Diano and colleagues (Diano et al., 2006), demonstrate novel actions of the orexigenic peptide ghrelin in hippocampal synaptic architecture, LTP, and learning and memory. These data suggest functional links between metabolic signaling and higher neural function.