in vertebrates and to determine the molecular and cellular basis for such currents. Methods: We use zebrafish caudal fin as an adult regeneration model. Specific ion flux measurements are done using a non-invasive Ion-Specific Scanning Microprobe coupled with transcriptional profiling and genetic functional analysis. Results: Our data points to an important role for protons (H[+]) during the re...

served not only in hip joints but also in the knee and other joints. Although regenerative medicine has recently seen a sudden resurgence of popularity, there seems to be a view that its use is limited to tissue regeneration by transplantation of tissue cultured in vitro using embryonic stem cells or somatic stem cells. However, I believe that regeneration of tissue by stimulating primitive mes...

Quantitative phase imaging enables precise characterization of cellular shape and motion. Variation of cell volume in populations of cardiomyocytes can help distinguish their types, while changes in optical thickness during beating cycle identify contraction and relaxation periods and elucidate cell dynamics. Parameters such as characteristic cycle shape, beating frequency, duration and regular...

The study of peripheral nerve injury, repair & rehabilitation began during the American Civil War and has since expanded to not only include to extensive characterization of the processes and factors that contribute to nerve regeneration and reinnervation, but also to determining therapies that enhance nerve regeneration such as physical modalities, rehabilitation consideration and recently bio...

The annual regrowth of deer antlers is a unique case of extensive appendage regeneration in mammals. This review compares basic aspects of antler regeneration with epimorphic regeneration in other vertebrate taxa. The mesenchymal cells that build up the regenerating antler are not derived from dedifferentiated cells in the pedicle stump, but from the proliferation of cells of the pedicle perios...

Galway, Ireland Dextran-tyramine Hydrogels for Cartilage Repair: Enhanced Chondrogenicity by Engraftment with Hyaluronic Acid and Heparin Liliana Moreira-Teixeira, Rong Jin, Piet Dijkstra, Clemens A. van Blitterswijk, Jan Feijen, Marcel Karperien Corresponding Author: [email protected] Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Med...

1 School of Psychology, Nanjing Normal University, Nanjing, China, 2 State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Hong Kong, China, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China, GHM Institute of CNS Regeneration, Jinan University, Guangzhou, China, Department of Ophthalmology, Li Ka Shing Faculty of M...

There are numerous available biodegradable materials that can be used as scaffolds in regenerative medicine. Currently, there is a huge emphasis on the designing phase of the scaffolds. Materials can be designed to have different properties in order to match the specific application. Modifying scaffolds enhances their bioactivity and improves the regeneration capacity. Modifications of the scaf...