Primary percutaneous coronary intervention, where available, has become the therapy of choice in myocardial reperfusion during ST-elevation myocardial infarction. However, in a significant proportion of patients, owing to a high thrombus burden, myocardial perfusion is not fully achieved in the epicardial vessel. This phenomenon has been attributed predominantly to the distal embolization of th...

6. Kennedy JW, Ritchie JL, Davis KB, Fritz JK. Western Washington rondomized trio1 of intracoronory streptokinase in acute myocordiol infarction. N Engl J Med 1983;309:1477-1482. 7. Schuler G. Schwarz F, Hofmann M, Mehmel H, Manthey J, Maurer W, Rauch B, Herrmann HJ, Kubler W. Thrombolysis in acute myocordiol injarction using intracoronary streptokinose: assessment by thallium-201 scintigraphy....

he coronary “no-reflow” phenomenon can occur during eperfusion of an infarct artery or after percutaneous coroary intervention (PCI) (1). It represents inadequate myoardial perfusion despite epicardial coronary artery patency nd can be caused by reperfusion injury, embolization of therosclerotic or thrombotic debris, or ischemia-induced icrovascular damage from endothelial cell injury, leukoyte...

Rupture of a vulnerable plaque and subsequent thrombus formation are important mechanisms leading to the development of an acute myocardial infarction (AMI). Typical intravascular ultrasound (IVUS) features of AMI include plaque rupture, thrombus, positive remodeling, attenuated plaque, spotty calcification, and thin-cap fibroatheroma. No-reflow phenomenon was attributable to the embolization o...

A. DEFINITION. The no-reflow phenomenon was originally observed in experimental models of acute myocardial infarction (MI) and was described as a failure to restore normal myocardial blood flow despite removal of the coronary obstruction. Since that time, no-reflow has been shown to complicate thrombolytic therapy and percutaneous revascularization with PTCA and other devices. Defined angiograp...

AIMS Early statin treatment has beneficial effects on prognosis after acute coronary syndrome. The no-reflow phenomenon determines the prognosis after acute myocardial infarction. We investigated the effects of statin treatment before admission on the development of the no-reflow after infarction. METHODS AND RESULTS We performed intracoronary myocardial contrast echocardiography in 293 conse...

OBJECTIVE The predictive value of five risk score models containing clinical (PAMI-PMS, GRACE-GRS, and modified ACEF-ACEFm-scores), angiographic SYNTAX score (SXS) and combined Clinical SYNTAX score (CSS) variables were evaluated for the incidence of three procedural complications of primary percutaneous coronary intervention (pPCI): iatrogenic coronary artery dissection, angiographically visib...

No-reflow phenomenon, defined as inadequate perfusion of myocardium without evident artery obstruction, occurs at a high incidence after coronary revascularization. The mechanisms underlying no-reflow is only partially understood. It is commonly caused by the swelling of endothelial cells, neutrophil accumulation, and vasoconstriction, which are all related to acute inflammation. Persistent no-...