The effect of dietary protein oil p70S5k phosphorylation was examined in rats starved for 18 h and then fed either a 20% casein diet (20C) er a protein-free diet (OC). Refeeding the 20C diet, but not the OC diet, increased p70Sdi phosphorylation in both the skeletal mllscle End liver. The plasma insulin concentratiens were the sEme after refeeding the 20C or OC diet, suggesting that a cembinati...

Gas chromatographic steroid metabolic profiling procedures have been applied to investigations of the effects of starvation and refeeding in mice. Urinary steroid metabolites were quantitatively followed during the starvation-refeeding experiments for mice with different genetic backgrounds. Some quantitative alterations were noted for certain congenic strains of mice. The metabolites which exh...

In this review we discuss the refeeding syndrome. This potentially lethal condition can be defined as severe electrolyte and fluid shifts associated with metabolic abnormalities in malnourished patients undergoing refeeding, whether orally, enterally, or parenterally. It can be associated with significant morbidity and mortality. Clinical features are fluid-balance abnormalities, abnormal gluco...

Fatty acid synthesis in the mammary gland of lactating rats in vivo was 5-fold higher than in the liver. Starvation decreased fatty acid synthesis in the gland 50-fold, whereas refeeding for 2h completely reversed this change. The plasma insulin concentration decreased 2-fold in starvation and was restored to the fed-rat value on refeeding. Glucagon and prolactin concentrations did not always c...

Lipogenic capacity of various dietary carbohydrates starch, glucose sucrose and lactose was tested during ad lib feeding and starvation followed by refeeding. Sucrose was found to have maximal effect on hepatic total lipid and the enzymes in the study followed by glucose and sago while lactose was found to be toxic. Starvation resulted depression in the activities of various enzymes. The enzyme...

The effects of fasting/refeeding and untreated or insulin-treated diabetes on the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and its mRNA in rat liver were determined. Both enzymatic activities fell to 20% of control values with fasting or streptozotocin-induced diabetes and were coordinately restored to normal within 48 h of refeeding or 24 h of insulin administra...

Tissue-specific alterations in insulin sensitivity occur in response to fasting and refeeding, as part of the integrated adaptive mechanisms employed to adjust to major changes in nutritional status. In the present study the effects of fasting and refeeding on insulin-receptor, actin and myosin mRNA levels in skeletal muscle, and insulin-receptor and uncoupling-protein mRNA in brown adipose tis...

The Inhibitor of DNA Binding/Differentiation (ID) proteins are a family of dominant negative regulators of the basic helix-loop-helix (bHLH) transcription factors, shown in mammals to delay cell differentiation and prolong proliferation. In the current study we used real-time PCR to investigate the effects of fasting and refeeding on the expression of ID genes in rainbow trout muscle. Fry short...

Refeeding syndrome is difficult to diagnose since the guidelines for identifying those at risk are largely based on subjective clinical parameters and there are no predictive biochemical markers. We examined the suitability of insulin-like growth factor 1 (IGF1) and leptin as markers to identify patients at risk of the refeeding syndrome before initiation of parenteral nutrition (PN). A total o...

BACKGROUND AND OBJECTIVES Refeeding hypophosphataemia (RH) is characterized by an acute electrolyte derangement following nutrition therapy. Complications associated include heart failure, respiratory failure, paraesthesia, seizure and death. We aim to assess its incidence, risk factors, and outcome in our local intensive care unit (ICU). METHODS AND STUDY DESIGN A prospective observational c...