BACKGROUND We aimed to study T-helper 1 (Th1) and Th2 intracellular cytokine expression in peripheral blood lymphocytes of women with recurrent spontaneous abortions (RSA) or infertility with multiple implantation failures after IVF cycles. METHODS Twenty-six women with three or more RSA and 23 with two or more IVF failures (14 with no history of spontaneous abortion (SAB) and nine with more ...

Recurrent Spontaneous Abortion (RSA) is a frequent pathology affecting 1 to 5% of couples. In approximately 50 % of cases, the aetiology is unknown suggesting a subtle interaction between genetic and environmental factors. Previous attempts to describe genetic factors using the candidate gene approach have been relatively unsuccessful due to the physiological, cellular and genetic complexity of...

Recurrent spontaneous abortion (RSA), defined as three or more sequential abortions before the twentieth week of gestation. Some studies have led to the awareness that immunological factors play an important role in establishing a successful pregnancy. The aim of present study was to investigate the relationship between RSA and polymorphisms of cytokine genes coding for TNF-α (-308 G→A, -238 G→...

PROBLEM To reveal the effect of p53-tristetraprolin-stathmin-1 signaling on trophoblasts and recurrent spontaneous abortion (RSA). METHOD OF STUDY Stathmin-1 (STMN1), p53, and tristetraprolin (TTP) expression in paraffin-embedded villus tissue was determined using immunohistochemistry. HTR-8/SVneo cells were treated with doxorubicin to activate p53; STMN1 and TTP levels were detected by quant...

Background: Recurrent spontaneous abortion (RSA), as a heterogeneous condition affects approximately 1- 3% of women in reproductive ages. Etiology of this frustrating disease in 40-50% is often unexplained. RSA as a traumatic event, especially with unclear etiology, could be followed by psychological squeal particularly anxiety. Emotion recovery, alongside investigation and medical treatment sh...

Background: There are different etiological factors in spontaneous recurrent abortion which are one of the complications in pregnancy. Primary embryo development in uterine tube and oviduct are affected by different factors such as embryotrophic elements. ETF3 as a embryotrophic factor that contains a complex of complement 3 protein and its derivatives specially iC3b, causes embryo trophoblast ...

OBJECTIVE The present study is aimed to analyze the expression of serum anticardiolipin antibody (ACA) and mononuclear cells of Tim-1 among the patients with negative anti paternal lymphocyte antibody (APLA) recurrent spontaneous abortion conducted by lymphocyte immunotherapy resulting in failure. PATIENTS AND METHODS 58 patients with negative APLA recurrent spontaneous abortion (RSA) who was...

Although the mechanisms causing recurrent spontaneous abortion (RSA) remain frequently speculative, recent evidence indicates that a specific uterine immune-endocrine network plays a pivotal role in the continuation of pregnancy. We have recently demonstrated that an adhesion molecule of the immune system, named intercellular adhesion molecule (ICAM)-1, is markedly expressed at both protein and...

Recurrent spontaneous abortion (RSA) occurs in 1‑5% of parturients. The sustained therapy and research for RSA is expensive, which is a serious issue faced by both patients and doctors. The aim of the present study was to detect protein expression profiles in the serum of RSA patients and healthy controls, and to identify potential biomarkers for this disease. A 1,000‑protein microarray consist...