Recurrent pregnancy loss is an important reproductive health issue, affecting 2%-5% of couples. Common established causes include uterine anomalies, antiphospholipid syndrome, hormonal and metabolic disorders, and cytogenetic abnormalities. Other etiologies have been proposed but are still considered controversial, such as chronic endometritis, inherited thrombophilias, luteal phase deficiency,...

Spontaneous abortion (SAB) is defined as the expulsion of a fetus before 20 weeks of gestation or weighing less than 500 g.’ Losses after 20 weeks are described as stillbirths or premature births and, generally, have different etiologies than losses earlier in gestation. The vast majority of SABs occur before 12 weeks of gestation. Those occurring at less than 8 weeks often do not contain an em...

This study was undertaken to explore whether intervention with heparin and aspirin (H/A) in selected patients undergoing in-vitro fertilization (IVF) and embryo transfer could improve fecundity rates. Specifically, it explored the possibility that women diagnosed with organic pelvic disease who demonstrated antiphospholipid antibodies (APA) could benefit from H/A administration in a similar man...

OBJECTIVE To determine any beneficial effects of preimplantation genetic screening (PGS) of all chromosomes by array comparative genomic hybridization (aCGH), with either day 3 or blastocyst biopsy, for idiopathic recurrent pregnancy loss (RPL) patients compared with their expected loss rate. DESIGN Case series report. SETTING Multiple fertility centers. PATIENT(S) A total of 287 cycles o...

In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). Although first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication suc...

Recurrent pregnancy loss (RPL) is usually defined as the loss of three or more consecutive pregnancies before 20 weeks of gestation. Within this definition is a large and heterogeneous group of patients with many different causes of miscarriage. RPL is a common clinical problem that occurs in approximately 1 % of reproductive-aged women. However, this frequency increases up to 5% when clinician...

This paper presents a novel approach to recurrent neural network (RNN) regularization. Differently from the widely adopted dropout method, which is applied to forward connections of feed-forward architectures or RNNs, we propose to drop neurons directly in recurrent connections in a way that does not cause loss of long-term memory. Our approach is as easy to implement and apply as the regular f...

background: miscarriage is a common phenomenon complicating more than half of pregnancies. recurrent pregnancy loss (rpl) is defined as three or more pregnancies lost before the twentieth week of gestation. it is believed that abnormality in maternal immune reaction to fetus and sharing of hla antigens might be associated with rpl. objective: to investigate the effect of hla-drb1 sharing betwee...

Abstract Background Polymorphism A1298C of the methylenetetrahydrofolate-reductase (MTHFR) gene has been implicated in spontaneous abortion. In this study, we determined the allele and genotype frequencies of this polymorphism in recurrent spontaneous abortion (RSA) and implantation failure after in vitro fertilization (IVF). Materials and Methods We performed a case–control study on 60 wom...