Necrotising fasciitis is a life-threatening soft tissue infection that is associated with high mortality and morbidity. It has been described in the form of Fournier's gangrene following rectal perforations related to colorectal cancer. In these rare instances, spontaneous perforation of locally-advanced rectal carcinoma provides an entry point for bacterial seeding to the surrounding soft tiss...

Secondary rectal linitis plastica is a very rare malignancy with poor prognosis. Diagnosis is difficult because of nonspecific clinical and endoscopic findings and negative biopsies in most cases owing to the fact that the mucosa is frequently unaffected. We herein describe a 68-year-old man who presented with a six-month history of tenesmus and constipation. Endoscopy revealed a narrow distal ...

cutaneous metastases, which revealed three sites of signet ring cell carcinoma. A 50-year-old woman presented with painless cutaneous nodules, along with a change in bowel habit and weight loss. She had no history of rectal bleeding. Skin examination revealedmultiple nodules on the left side of her neck (●" Fig. 1a), below her right breast, onherback in a zoster-like distribution, and in the pe...

AIMS To evaluate the influence of involvement of the peritoneal surface by carcinoma of the rectum on local recurrence and prognosis. METHODS Prospective analysis of pathological prognostic factors in 209 resections for rectal carcinoma between 1988 and 1993 with meticulous pathological technique particularly to assess the relation of tumour to the peritoneal surface. Comprehensive clinical f...

Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma. After the (11;14) translocation was identified as its constant finding in 1992, MCL was recognized as a separate subgroup of non-Hodgkin lymphoma (NHL). In MCL, extranodal involvement may be observed in the bone marrow, the spleen, the liver, and the gastrointestinal system (GIS). Cases of MCL that present with a massive and so...

The total lactic dehydrogenase (LD) content and LD isoenzyme ratios were studied in homogenized rectal mucosa from 31 patients with established non-specific mucosal ulcerative colitis and from 16 normal subjects. The total LD content was found to be significantly increased in patients with active ulcerative colitis when compared with patients with inactive colitis or with normal subjects. There...

Colorectal cancer is a heterogeneous disease that arises from multiple tumorigenic pathways [1–6]. Colon and rectal adenocarcinomas are the result of a stepwise progression from normal tissue to dysplastic epithelium to carcinoma – referred to as the adenoma–carcinoma sequence – which is accompanied by multiple genetic alterations including oncogenes, the activation and inactivation of tumour s...