The genetic control of susceptibility to two species of murine malarial parasites was investigated with recombinant inbred (RI) mouse strains as a model system. Initially, the nonlethal Plasmodium yoelii 17X strain was cloned by limiting dilution to minimize parasite variability. This cloned P. yoelii was used to infect C57BL and BALB/c mice, strains which are the progenitors of the CXB RI stra...

DNA sequences homologous to adult alpha-globin genes are dispersed in the mouse. Two functional genes are tightly linked on chromosome 11. Pseudogenes have been assigned to chromosomes 15 and 17 by analysis of interspecies somatic cell hybrids. We have now further characterized the second of these pseudogenes, Hba-a4. The gene is highly polymorphic, with three forms occurring in a panel of 15 i...

The biomechanical properties of the cornea and sclera are important in onset progression multiple ocular pathologies vary substantially between individuals, yet source this variation remains unknown. Here we identify genes putatively regulating corneoscleral tissue by conducting high-fidelity compliance measurements across BXD recombinant inbred mouse set performing quantitative trait analysis....

Corn borers are the most important pest affecting maize. Resistance to corn borer attack may compromise plant fitness being detrimental for some agronomic traits such as yield. Against of this pest, cell wall-bound hydroxycinnamates have been previously described a possible defense mechanism. In study, characterization and quantification was performed in subset Recombinant Inbred Lines (RILs) f...

In order to increase the fiber productivity in cotton, it is imperative genetically improve component traits and such effort can be quickened by use of molecular markers. Totally, seventy-four simple sequence repeat (SSR) markers that were previously shown linked fibre strength, boll weight, elongation used differentiate Gossypium hirsutum var. MCU5 TCH1218 among them two found polymorphic Thes...

Genetic linkage analysis in the laboratory mouse identified chromosomal regions containing genes that contribute to cholesterol accumulation in the liver and plasma. Comparisons between five inbred strains of mice obtained from the Jackson Laboratory (DBA/2, AKR, C57BL/6, SJL, and 129P3) revealed a direct correlation between intestinal cholesterol absorption and susceptibility to diet-induced h...

Abstract Spike fertility index (SF) is a trait easily measured at maturity and strongly associated with the number of grains per unit area. In order to identify genomic regions involved in SF control, biparental (Baguette 10 × Klein Chaja) population 80 recombinant inbred lines (RIL) was used. Seven field trails were conducted determine BLUP value RIL. RILs genotyped using commercial chip (Axio...

The ribosomal DNA (rDNA) in Tetrahymena thermophila is a 21-kilobase-pair palindromic DNA molecule that replicates autonomously in the macronucleus and is maintained at the level of about 10,000 copies per macronucleus. The rDNA of inbred strain C3 outreplicates the rDNA of inbred strain B in most B/C3 heterozygous macronuclei, generating macronuclei containing exclusively C3 rDNA sequences. In...

We consider recombinant inbred lines obtained by crossing two given homozygous parents and then applying multiple generations of self-crossings or full-sib matings. The chromosomal content of any such line forms a mosaic of blocks, each alternatively inherited identically by descent from one of the parents. Quantifying the statistical properties of such mosaic genomes has remained an open chall...

Inbred strains of mice excrete all three major urinary proteins (mups) when induced by testosterone, but differ as to the relative proportions and total levels of each mup present. We have now determined the urinary mup phenotypes before and after testosterone treatment of seven recombinant inbred strains derived from progenitor strains exhibiting different mup phenotypes. The results confirm p...