background: considering the effect of preterm delivery in morbidity and mortality of newborns, its precaution and prevention is so important. objective: to investigate the association between second trimester maternal serum biomarkers (human chorionic gonadotropin, alpha-fetoprotein, non-conjugated estrogen, inhibin a) and pre-term delivery. materials and methods: this is a historical cohort st...

Introduction: Considering the high incidence of preterm labor and its known complications, and that human myometrium contains receptors for human chronic gonadotropin (hCG) and that hCG can inhibit myometrial contractions on vitro, made me study treating effects of hCG on preterm labor. This clinical trial study was carried out to compare the effect of hCG, and magnesium sulfate (mgso4) on pre...

BACKGROUND The aim of this meta-analysis was to evaluate the role of androgens or androgen-modulating agents on the probability of pregnancy achievement in poor responders undergoing IVF. METHODS Medline, EMBASE, CENTRAL, Scopus and Web of Science databases were searched for the identification of randomized controlled trials evaluating the administration of testosterone, dehydroepiandrosteron...

background: no consensus has been reached on prognostic value of serum concentration of β (beta) subunit of human chorionic gonadotropin (β-hcg) in treatment response to methotrexate in management of ectopic pregnancy. therefore, the present study aimed to evaluate this subject through a systematic review and meta-analysis. materials and methods: an extensive literature search on online databas...

Background Stimulatory therapy with gonadotrpins is an effective treatment to induce spermatogenesis in men with idiopathic hypogonadotroptic hypogonadism (IHH). The aim of this study was to assess the effectiveness of human chorionic gonadotropin / human menopausal gonadotropin on hypogonadotropic infertile men. MaterialsAndMethods This study included fifty-six azoospermic infertile men with I...

Family physicians often use quantitative human chorionic gonadotropin (HCG) testing to assess first-trimester bleeding. While we anticipate a range of normal results for any given week in the first trimester, we predict an approximate doubling over 48 hours in a normal pregnancy during the first trimester. Human chorionic gonadotropin tends to peak at about 10 weeks’ gestation before declining ...

Fully Automated Chemiluminometric Assay for Hyperglycosylated Human Chorionic Gonadotropin (Invasive Trophoblast Antigen), Raj Pandian, Julie Lu, and Jolanta Ossolinska-Plewnia ( Quest Diagnostics, Nichols Institute, 33608, Ortega Highway, San Juan Capistrano, CA 92690; 2 Nichols Institute Diagnostics, San Clemente, CA 92673; * author for correspondence: fax 949-728-4990, e-mail pandianr@questd...

HCG is composed of two subunits, HCGalpha and HCGbeta. During early pregnancy, HCG stimulates progesterone production in the corpus luteum, and injection of HCG is widely used to induce ovulation in assisted reproduction treatment (ART). Under experimental conditions, the free subunits have been shown to exert functions other than those of HCG, but the relevance of these remains to be determine...