Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging...

mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...

Among the different causes of gynecological acute pelvic pain, ovarian torsion represents a surgical emergency. It is a rare case in the pediatric/adolescent aged group that must be included in the differential diagnosis of any girl with abdominal pain or pelvic/abdominal mass. Current recommendations suggest that laparoscopic detorsion should be performed in order to preserve the integrity of ...

2009 2 CONTENTS 1. INTRODUCTION 9 1.1. Free radicals and their derivatives in living organisms 9 1.1.1. Reactive oxygen species (ROS) 11 1.1.2. Reactive nitrogen species (RNS) 13 1.1.3. Protective mechanisms against free radicals.

Abbreviations: ESKAPE: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter Baumanni, Pseudomonas Aeruginosa, and Enterobacter species; FI: Faecal Incontinence; LED: Light Emitting Diode; PDT: Photodynamic Therapy; ROS: Reactive Oxygen Species; rUTI: Recurrent UTI; UI: Urinary UTI: Tract Infection; uUTI: Uncomplicated human UTI

Reactive oxygen species (ROS), as well as reactive nitrogen species (RNS), are products of normal cellular metabolism. ROS and RNS are well recognized for playing a dual role as both deleterious and beneficial species, since they can be either harmful or beneficial to living systems (Valko et al., 2006). Beneficial effects of ROS occur at low/moderate concentrations and involve physiological ro...

Introduction: D-galactose (D-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. In the present study, we selected crocin, the main constituent of Crocus sativus L. (Saffron), against D-gal cytotoxicity in human neuroblastoma SH-SY5Y cells. Materials and Methods:  Cells were pretreated with crocin (25-500 µM) for 24 h and then expos...