Imatinib and its analogues were successfully synthesized by an improved method in 19.5– 46.2% total yield of six main steps. Pyrimidinyl amine was prepared by the reaction of enaminone and guanidine nitrate without the use of a toxic cyanamide. N-(2Methyl-5-nitrophenyl)-4-(pyridin-3-yl) pyrimidin-2-amine as a key intermediate for the synthesis of imatinib was prepared by coppercatalyzed N-aryla...

Photosynthetic bacteria contain bacteriochlorophyll (BChl) that absorbs light and delivers the resulting singlet excitation energy to photochemical reaction centers.' The reaction centers, which have been isolated in a form free of lightharvesting BChl,'-3 contain a photochemically specialized BChl which in Rhodopseudomonas spheroides is called P870 after its absorption maximum near 870 nm. Exc...

Depolymerization behavior polyesters (poly(ethylene terephthalate) (PET) and poly(ethylene 2,6-naphthalene dicarboxylate) (PEN)) in suband supercritical water was investigated for the purpose of monomer recycling. In case of the depolymerization of PET, the yield of terephthalic acid (TPA) increased to 90 % with increasing reaction temperature up to 693 K while the maximum yield of ethylene gly...

An efficient synthesis of the 1-hydroxy-2-(prop-2'-enyl)9-anthrone is described. Selective nitration of anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-9,10-anthraquinone in good yield as the key intermediate. Reaction with allyl bromide/K2CO3 and subsequent selective reduction accompanie...

a simple extremely fast and efficient approach for the synthesis of substituted indazole ingood to excellent yield catalyzed by using silica sulfuric acid (ssa) in dmso solvent at roomtemperature. this is solid state reaction have been attracting the synthetic organic chemist asthey provided enhance reaction rates, less environmental pollution, greater selectivity, cleanerproducts and manipulat...

This paper demonstrates that the ability of the yield spread to predict output fluctuations is contingent on the monetary authority’s reaction function. In particular, expectations of monetary policy actions are crucial for the spread to predict output conditional on the short-rate. Furthermore, numerical experiments suggest that the post-1979 decrease in the yield spread’s predictive power is ...

Nitration of potassium sulphamate was carried out using a mixture of sulphuric and nitric acid at -30 °C. The reaction time was optimized at the mole ratio of sulphuric to nitric acid of (1:3.5). The difference in product yield by changing the potassium to ammonium sulphamate was studied throughly. It was found that both the yield and purity of the product is better starting with potassium ...

the synthesis of 3-amino-1-nitroguanidine (3-anq) and 5-hydrazino tetrazole (5-ht) derivatives as new energetic materials are described. reaction of 3-anq with triethyl orthoformate leads to the formation of 3-nitramino triazole while no reaction was observed whit 5-ht. addition of nan3 to a mixture of 3-anq and triethyl orthoformate, afforded 1-nitroguanidyl tetrazole in excellent yield. on th...

The reduction of aldehydes by flavohydroquinone to yield the corresponding alcohols and flavoquinone is reported and discussed in view of its relevance to the mechanism of flavin-dependent dehydrogenation and carbonyl activation. With formaldehyde and flavohydroquinone formation of a covalent 5(HO — CH2)Fl red~ intermediate species is observed. In a reverse reaction 5-methylflavoquinonium catio...