The visual cycle is a series of enzyme-catalyzed reactions which converts all-trans-retinal to 11-cis-retinal for the regeneration of visual pigments in rod and cone photoreceptor cells. Although essential for vision, 11-cis-retinal like all-trans-retinal is highly toxic due to its highly reactive aldehyde group and has to be detoxified by either reduction to retinol or sequestration within ret...

CONTEXT In the Australia Northern Territory (NT), the health service and especially Royal Darwin Hospital (RDH) faces many unique and special challenges related to the diversity of its population and its remoteness. The NT population is vast and varied, both culturally and geographically, and there are long distances between communities. Represented among the many cultures present in the NT are...

RDH10 (retinol dehydrogenase 10) was originally identified from the retinal pigment epithelium and retinal Müller cells. It has retinoid oxidoreductase activity and is thought to play a role in the retinoid visual cycle. A recent study showed that RDH10 is essential for generating retinoic acid at early embryonic stages. The present study demonstrated that wild-type RDH10 catalysed both oxidati...

BACKGROUND Crusted scabies, or hyperinfestation with Sarcoptes scabiei, occurs in people with an inadequate immune response to the mite. In recent decades, data have emerged suggesting that treatment of crusted scabies with oral ivermectin combined with topical agents leads to lower mortality, but there are no generally accepted tools for describing disease severity. Here, we describe a clinica...

Retinoic Acid (RA) is a small lipophilic signaling molecule essential for embryonic development and adult tissue maintenance. Both an excess of RA and a deficiency of RA can cause pathogenic anomalies, hence it is critical to understand the mechanisms controlling the spatial and temporal distribution of RA. However, our current understanding of these processes remains incomplete. Vitamin A is m...

BACKGROUND AND PURPOSE The significance of postoperative nerve root changes (enhancement, thickening, and displacement) is still a topic of debate. The purpose of this study was to evaluate the association between nerve root changes and residual or recurrent symptoms after lumbar surgery with contrast-enhanced MR imaging. MATERIALS AND METHODS A total of 120 patients with 140 postoperative lu...

S : scientific #bd14 | big data conference 22 Dr Xiongcai (Peter) Cai Research Fellow Centre for Health Informatics, The University of New South Wales Dr Xiongcai (Peter) Cai is a researcher with a general background in AI with expertise in the fields of machine learning, data mining, social network analysis and health informatics. He has been spending the past decade researching and developing...

Reductive dehalogenases are essential enzymes in organohalide respiration and consist of a catalytic subunit A and a membrane protein B, encoded by rdhAB genes. Thirty-two rdhAB genes exist in the genome of Dehalococcoides mccartyi strain CBDB1. To gain a first insight into the regulation of rdh operons, the control of gene expression of two rdhAB genes (cbdbA1453/cbdbA1452 and cbdbA1455/cbdbA1...

New, more and more aid is square to reversible data hiding (RDH) in encrypted images, since it maintains the fantabulous property that the germinal conceal can be lossless recovered after embedded data is extracted while protecting the person proportionality's confidentiality. All early methods embed assemblage by reversibly vacating space from the encrypted images, which may be thing to both e...