BACKGROUND High concentrations of homocysteine have been linked to a greater risk of Alzheimer disease, dementia, and cognitive decline. OBJECTIVE We evaluated the association between homocysteine and 4.5-y combined incidences of dementia and cognitive impairment without dementia (CIND) in a cohort of 1779 Mexican Americans aged 60-101 y. DESIGN Homocysteine, red blood cell (RBC) folate, an...

The study aimed to examine the external validity of the Folate Food Frequency Questionnaire (F-FFQ) designed for assessing the folate intake in Serbian women of reproductive age. The F-FFQ was tested against repeated 24 h dietary recalls and correspondent nutritional biomarkers (red blood cells (RBC) and serum folate concentrations) using the method of triads. In a cross sectional study, 503 wo...

Exposure to oxygen-rich environments can lead to oxidative damage, increased body iron stores, and changes in status of some vitamins, including folate. Assessing the type of oxidative damage in these environments and determining its relationships with changes in folate status are important for defining nutrient requirements and designing countermeasures to mitigate these effects. Responses of ...

HE ESSENTIAL role of intracellular folates in ef-T fecting one-carbon transfers in critical enzyme systems for DNA synthesis is well This has led to extensive application of various synthetic folate analogues as therapeutic and investigative tools in a variety of infectious, immunologic, and neoplastic diseases, as well as in developmental, transplantation, and tumor b i o l ~ g y. ~ , ~ While ...

Epidemiologic data suggest that increasing folate intake may protect against colorectal cancer. Riboflavin may interact with folate to modulate the effect. A double-blind randomized placebo-controlled intervention study (the FAB2 Study) was carried out in healthy controls and patients with colorectal polyps (adenomatous and hyperplastic) to examine effects of folic acid and riboflavin supplemen...

Folate is the generic name for all derivatives of the B a controlled dietary intervention study that a diet high in vitamin with the biological activity of pteroylmonogdietary folate from vegetables and citrus fruit (560 mg/d) lutamic acid. Folic acid is the fully oxidised monoglutadecreased plasma total homocysteine concentrations and mate form of the vitamin, whereas the other naturally impro...

Lometrexol inhibits the first folate-dependent enzyme in de novo purine biosynthesis and is avidly polyglutamated and retained in tissues expressing folylpolyglutamate synthetase. Although clinical studies have been limited by cumulative toxicity, preclinical studies show that pretreatment with folic acid can protect normal tissue while maintaining tumor cytotoxicity. Therefore, a Phase I study...

The clinical picture is the most important factor in assessing the significance of test results assessing cobalamin status because there is no 'gold standard' test to define deficiency. Serum cobalamin currently remains the first-line test, with additional second-line plasma methylmalonic acid to help clarify uncertainties of underlying biochemical/functional deficiencies. Serum holotranscobala...