نتایج جستجو برای: razy 251

تعداد نتایج: 6748  

2006
G LAKE-BAKAAR

251-labelled human trypsin metabolism has been investigated in man. Three subjects received 1251-trypsin and 1311-albumin intravenously. Against a background secretin infusion (lu/kg/h), trypsin decayed biexponentially from the serum with half-lives of 17.5, 21, and 24 minutes for the rapid disappearance phase and 520, 540, and 560 minutes for the slow phase. Between 130% and 38% of the 1251 in...

2002
JEAN P. CHRISTOPHE THOMAS P. CONLON JERRY D. GARDNER

We have used ‘251-laheled vasoactive intestinal peptide (VIP) to study the kinetics, stoichiometry, and chemical specificity with which the labeled peptide binds to dispersed acinar cells prepared from guinea pig pancreas. Binding of ‘2”I-VIP to pancreatic acinar cells was moderately rapid, reversible, specific, saturable, and depended on incubation temperature. Deterioration of ‘2sI-VIP incuba...

Journal: :Iranian journal of immunology : IJI 2013
Sadaf Asaei Manoochehr Rasouli Ali Moravej

BACKGROUND Increased levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in acute human brucellosis have been reported. Previous studies have shown that the production and level of IL-6 and IL-8 cytokines are associated with the polymorphism of the encoding genes. OBJECTIVE To investigate the probable association between IL-6 (-174 C/G) and IL-8 (-251 A/T) gene polymorphisms and susceptib...

Journal: :Cancer research 2008
Rebecca Kinkade Piyali Dasgupta Adam Carie Daniele Pernazza Melanie Carless Smitha Pillai Nicholas Lawrence Said M Sebti Srikumar Chellappan

Although it is well established that cyclin-dependent kinases phosphorylate and inactivate Rb, the Raf-1 kinase physically interacts with Rb and initiates the phosphorylation cascade early in the cell cycle. We have identified an orally active small molecule, Rb/Raf-1 disruptor 251 (RRD-251), that potently and selectively disrupts the Rb/Raf-1 but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/...

Journal: :Biblica et Patristica Thoruniensia 2023

Mariologia nie jest tematem centralnym Homilii Paschalnej Melitona z Sardes, ale pojawia się zawsze w kontekście rozważań na temat zbawczej roli Chrystusa. Maryja tekście cztery razy, r. 66, 70, 71 i 104, czego trzy razy pierwszej jej części dotyczącej typologicznej interpretacji Wj 12 (r. 70 71) jeden raz Epilogu (r.104). W Meliton przedstawia tajemnicę wcielenia słowami „On to Dziewicy wziął ...

Journal: :International Journal of Phonosurgery & Laryngology 2011

2014
Giovanni Luca Gravina Monica Tortoreto Andrea Mancini Alessandro Addis Ernesto Di Cesare Andrea Lenzi Yosef Landesman Dilara McCauley Michael Kauffman Sharon Shacham Nadia Zaffaroni Claudio Festuccia

BACKGROUND Exportin 1 (XPO1), also called chromosome region maintenance 1 (CRM1), is the sole exportin mediating transport of many multiple tumor suppressor proteins out of the nucleus. AIM AND METHODS To verify the hypothesis that XPO1 inhibition affects prostate cancer (PCa) metastatic potential, orally available, potent and selective, SINE compounds, Selinexor (KPT- 330) and KPT-251, were ...

Journal: :The Journal of biological chemistry 1976
R Kleppe T Sekiya P C Loewen K Kleppe K L Agarwal H Büchi P Besmer M H Caruthers P J Cashion M Fridkin E Jay A Kumar R C Miller K Minamoto A Panet U L RajBhandary B Ramamoorthy N Sidorova T Takeya J H van de Sande H G Khorana

The DNA duplex corresponding to the entire length (126 nucleotides) of the precursor for an Escherichia coli tyrosine tRNA has been synthesized. Duplex [I] (Sekiya, T., Besmer, P., Takeya, T., and Khorana, H. G.(1976) J. Biol. Chem. 251, 634-641), corresponding to the nucleotide sequence 1-26, containing single-stranded ends and carrying one appropriately labeled 5'-phosphate group, was joined ...

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