نتایج جستجو برای: rat aortic rings

تعداد نتایج: 429725  

2011
Gonzalo Allende Salvador Acevedo

It is known that vasodilator effects of adenosine are mediated by A2 receptors in various animal species. Nevertheless, in several blood vessels there is evidence for vasodilator responses to some adenosine analogues, which are resistant to the antagonists of the different adenosine receptor subtypes, suggesting that they are not mediated by any of the known adenosine receptors. There are contr...

2009
David R Kamadyaapa Mavuto M Gondwe Kogi Moodley Cephas T Musabayane John AO Ojewole

The purpose of this study was to examine the in vivo effects of Ekebergia capensis leaf ethanolic extract (EKE) on the blood pressure of anaesthetised normotensive male Wistar rats and conscious weanling Dahl salt-sensitive (DSS) rats, which develop hypertension as they age. To investigate possible mechanism(s) of the extract's hypotensive effects, the contractile or relaxant responses to EKE i...

Journal: :American journal of physiology. Heart and circulatory physiology 1999
G J Christ M Spektor P R Brink L Barr

The lack of selective gap junctional uncoupling agents has hampered evaluation of the contribution of intercellular communication to pharmacomechanical coupling and vascular contractility. Thus we further explored the utility and selectivity of heptanol as a gap junctional uncoupling agent in isolated rat aortic rings. Fifty-two aortic rings were obtained from 15 rats and were precontracted to ...

Journal: :Hypertension 2001
R A Beswick A M Dorrance R Leite R C Webb

We previously reported increased aortic reactive oxygen species (ROS) production in mineralocorticoid (deoxycorticosterone acetate [DOCA]-salt) hypertensive rats. In the present study, we tested the hypothesis that NADH/NADPH oxidase is responsible for increased ROS production, namely superoxide (O(2-)), in aorta from the DOCA-salt rat. Treatment of aortic rings from DOCA-salt rats with the NO ...

ژورنال: دانشور پزشکی 2009
بلوچ‌نژادمجرد, دکتر توراندخت , روغنی, دکتر مهرداد , طاعتی, ریحانه , واعظ مهدوی, دکتر محمدرضا ,

  Background & Objective : Food restriction has a protective effect against damaging agents and prevents cardiovascular disorders. This study was conducted to evaluate the effect of food restriction on contractile reactivity of male rats using isolated tissue setup.  Materials & Methods: Male Wistar rats were randomly divided into one control and three experimental groups. Control group receive...

Journal: :Circulation research 1991
V B Schini P M Vanhoutte

This study was designed to investigate the effects of L-arginine (the substrate for the formation of endothelium-derived nitric oxide) in vascular tissues. Rat aortic rings, with or without endothelium, were suspended in organ chambers for the measurement of isometric tension; they were contracted with phenylephrine (10(-6) M). After a short incubation period (0.5 hour) in physiological salt so...

2014
Rocío Salsoso Enrique Guzmán-Gutiérrez Pablo Arroyo Carlos Salomón Sonia Zambrano María Victoria Ruiz-Armenta Antonio Jesús Blanca Fabián Pardo Andrea Leiva Alfonso Mate Luis Sobrevia Carmen María Vázquez

Impaired L-carnitine uptake correlates with higher blood pressure in adult men, and L-carnitine restores endothelial function in aortic rings from spontaneously hypertensive rat (SHR). Thus, endothelial dysfunction in hypertension could result from lower L-carnitine transport in this cell type. L-Carnitine transport is mainly mediated by novel organic cation transporters 1 (Octn1, Na(+)-indepen...

Journal: :The Journal of pharmacology and experimental therapeutics 2003
Jacicarlos L Alencar Irina Lobysheva Karel Chalupsky Michel Geffard Françoise Nepveu Jean-Claude Stoclet Bernard Muller

The ability of various nitric oxide (NO) donors to induce long-lasting inhibition of contraction in isolated arteries was compared. All the studied compounds elicited a relaxant effect in rat aortic rings precontracted with norepinephrine (NE). Almost maximal relaxation was obtained with 1 microM of each compound. The S-nitrosating agents S-nitrosoglutathione (GSNO), S-nitroso-N-acetylpenicilla...

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