background: endometrial cancer is the most common gynecologic malignancy that has often proceeded by a premalignant phase. modern molecular and immune staining methods for precancerous lesions diagnosis have been expanded. one of the genetic alternations in the endometrial cancer carcinogenesis is the mutational activation of the k-ras oncogene. k-ras mutation has recognized to occur at an earl...

Introduction Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory oral mucosa disease with an unknown cause. However, dysregulation of the immune response seems to play an important role in this disease. Aim To evaluate the vitamin D status in RAS patients and its effects on RAS severity, given the likely immunomodulatory function of vitamin D in the human organism. Material...

BACKGROUND Oncogenic mutations of PIK3CA, RAS (KRAS, NRAS), and BRAF have been identified in various malignancies, and activate the PI3K/AKT/mTOR and RAS/RAF/MEK pathways, respectively. Both pathways are critical drivers of tumorigenesis. METHODS Tumor tissues from 504 patients with diverse cancers referred to the Clinical Center for Targeted Therapy at MD Anderson Cancer Center starting in O...

Statins and renin-angiotensin system (RAS) blockers are key drugs for treating patients with an acute myocardial infarction (AMI). This study was designed to show the association between treatment with statins or RAS blockers and clinical outcomes and the efficacy of two drug combination therapies in patients with ischemic heart failure (IHF) who underwent revascularization for an AMI. A total ...

EARLY DEVELOPMENT OF DICTYOSTELIUM DISCOIDEUM.................................................... 29 GENETIC ANALYSIS.................................................. 30 MUTANTS ALTERED IN AGGREGATION.................................................. 32 Numbers of Genes .................................................. 32 Selection Procedures.................................................. ...

Recurrent Aphthous Stomatitis (RAS) is a prevalent oral disease that detrimentally impacts the quality of life for those affected. One several factors can trigger emergence RAS stress. Psychological stress adversely affect health and decrease immune system. Studies in field Psychoneuroimmunology have shown relationship between human behaviour, nerve function, psychological stress, which potenti...

Writers’ identity (Ivanič, 1998) and positioning in written text have been studied under multiple terms. However, a clearer distinction should be made between writers’ (Hyland, 2005a) presence or voice (John, 2005). This paper explores how disseminators specialised writers adapt mediate the of researchers medical research articles (Med-RAs) corresponding popularizations published on-line (Med-E...

Summary K-ras mutations are found in 40-50% of human colorectal adenomas and carcinomas, but their functional contribution remains incompletely understood. Here, we show that a conditional mutant K-ras mouse model (K-ras(Asp12)/Cre), with transient intestinal Cre activation by beta-Naphthoflavone (beta-NF) treatment, displayed transgene recombination and K-ras(Asp12) expression in the murine in...

19 20 While there have been tremendous efforts to target oncogenic RAS signaling 21 from inside the cell, little effort has focused on the cell-surface. Here, we used 22 quantitative surface proteomics to reveal a signature of proteins that are 23 upregulated on cells transformed with KRASG12V, and driven by MAPK pathway 24 signaling. We next generated a toolkit of recombinant antibodies to sev...