Poly(ADP-ribose) polymerase (PARP) inhibitors enhance the effect of DNA alkylating agents on BRCA1‑ and BRCA2-deficient cell lines. The aim of this study was to analyze the effect of the PARP inhibitor nicotinamide (NAM) on breast cancer cells with different BRCA1 expression or function, such as BRCA1‑deficient MDA-MB-436 cells, low expression BRCA1 MCF-7 cells, and the BRCA1 wild‑type MDA-MB-2...

We present a new cryptosystem based on ideal arithmetic in quadratic orders. The method of our trapdoor is diierent from the Diie-Hellman key distribution scheme or the RSA cryp-tosystem. The plaintext m is encrypted by mp r , where p is a xed element and r is a random integer, so our proposed cryptosystem is a probabilistic encryption scheme and has the ho-momorphy property. The most prominent...

Under various appropriate hypotheses it is shown that there is only one determinacy model of the form L(R, μ) in which μ is a supercompact measure on Pω1(R). This gives a positive answer to a question asked by W.H. Woodin in 1983.

Recent research has shown that the subskills and text types affect reader performance considerably (Lumley, 1993, Dennis, 1982). Despite the fact that most reading tests consist of a variety of subskills and text types at the same time, the studies about the relative effects of both subskills and text types on readers’ performance are rare. In that vein, this article reports the relative effect...

Being composed of several whorls of distinct floral organs, the flower is one of the most complex organs in the plant. As such, the formation and maintenance of boundaries that separate the meristem from the floral organ primordium and adjacent organs are critical for its normal development. In Arabidopsis, the miR164-regulated NAM genes play key roles in floral-boundary specification. By contr...

This paper describes the system parameters and software implementation of a HECDSA cryptosystem based on genus-2 hyperelliptic curves over prime fields. We show how to reduce the computational complexity for special cases and compare the given cryptosystem with the well-known ECDSA cryptosystem based on elliptic curves.

The standard RSA cryptosystem is not semantically secure. Pointcheviel proposed a variant of RSA cryptosystem with the property of semantic security by introducing a new problem known as DRSA problem. He called it DRSA scheme. In this paper, we underlined a shortcoming of that scheme and proposed an alternative DRSA public key cryptosystem.

An analogue of McEliece’s cryptosystem, the Gabidulin-Paramonov-Trejtakov (GPT) public-key cryptosystem is based on rank-metric-based Gabidulin codes instead of Goppa codes. The GPT cryptosystem has attracted steady attention since it is much more robust against the decoding attacks and can therefore achieve the same level of security with much smaller keys. The key sizes, nonetheless, may stil...

The cryptosystem proposed by Koyama is not semantically secure. Also, it is not secure against partial known plaintext attack, linearly related plaintext attack and low exponent attack. In this paper we propose a cryptosystem over singular cubic curve using the idea of Koyama and Kouichi et al. Our proposed cryptosystem is approximately two times faster than the cryptosystem given by Kouichi et...