Background: Long-term treatment of rheumatoid arthritis (RA) with prednisolone (PRED) is associated with bone mineral density (BMD) loss. This study aimed to determine the status of BMD in non-compliant women who used PRED alone for RA. Methods: Non-adherent RA taking < 7.5 mg daily PRED without DMARDs for > 6 months, and RA patients taking methotrexate +PRED (RA control) were compared with ag...

OBJECTIVES Cigarette smoking is a major risk factor for RA and has been associated with increased disease severity and lower rates of disease remission. We hypothesized that inflammation and disease activity would be associated with smoking status and this would be related to levels of ACPA. METHODS RA patients from the Veterans Affairs RA registry were studied (n = 1466): 76.9% anti-CCP2 pos...

in this research, the effects of organic fertilizers (bovine, sheep, leaf mould and vermicompost fertilizers) combined with foliar application of salicylic acid (sa) at the rate of 0, 10-2, 10-4 and 10-6 m on essential oil percentage and some secondary metabolites of lemon balm were investigated. the experiment was conducted as complete randomized block design with factorial arrangement in pots...

BACKGROUND Interstitial lung disease (ILD) is associated with high morbidity and mortality in rheumatoid arthritis (RA). Citrullinated proteins are observed in RA lung tissues; however, the association of specific anticitrullinated peptide antibodies (ACPA) with ILD in RA is unknown. METHODS RA patients underwent multidetector CT (MDCT) of the chest, from which ILD features and a semiquantita...

We investigate the transient and stationary buoyant motion of the Rayleigh-Bénard instability when the fluid layer is subjected to a vertical, steady magnetic field. For Rayleigh number, Ra, in the range 103-106, and Hartmann number, Ha, between 0 and 100, we performed three-dimensional direct numerical simulations. To predict the growth rate and the wavelength of the initial regime observed wi...

A method of two-dimensional infrared (2D IR) spectroscopy called relaxation-assisted 2D IR (RA 2DIR) is proposed that utilizes vibrational energy relaxation transport in molecules to enhance cross-peak amplitudes. This method substantially increases the range of distances accessible by 2D IR and is capable of identifying long-range connectivity patterns in molecules. RA 2DIR is illustrated in i...

INTRODUCTION Advanced glycation end products (AGEs) are produced and can accumulate during chronic inflammation, as might be present in patients with rheumatoid arthritis (RA). AGEs are involved in the development of cardiovascular disease. The aim of this study is to evaluate whether AGEs are increased in patients with long-standing RA and whether AGE accumulation is related to disease activit...

Background: Patients with rheumatoid arthritis (RA) suffer from wide ranges of autoimmune reactions in joints. The mechanism of which is generally unknown and maybe associated with Treg deregulation. Objective: To compare the frequency of nTregs in peripheral blood of patients with active rheumatoid disease with healthy individuals. Methods: Twenty five newly diagnosed patients with active RA d...

The aim of the present study was to perform an immunohistological assessment of the synovial tissue from involved small joints in rheumatoid arthritis (RA) and to explore the reliability of a mini-invasive ultrasound (US)-guided technique of small joint synovial biopsy for the histopathological assessment. Synovial tissue collected during arthrotomic surgery of small joints in nine patients ser...

OBJECTIVE The Disease Activity Score including 28 joints (DAS28) and the Clinical Disease Activity Index (CDAI) were developed in order to provide a quantifiable measure of rheumatoid arthritis (RA) activity. The aim of this study was to evaluate the validity and internal consistency reliability for DAS28 and CDAI in patients with RA seen by rheumatologists in usual clinical care. We also compa...