The randomized clinical trial (RCT) and systematic review underpin evidence-based medicine. They are perceived to provide the strongest evidence on interventions—when viewed as part of an evidence hierarchy, and are generally accepted as such, in clinical medicine. Yet, they are perceived to have limited currency in health promotion practice. Those trying to build bridges across these fields ha...

PURPOSE OF REVIEW Idiopathic inflammatory myopathies (IIMs) are complex multisystemic autoimmune diseases. Glucocorticoids remain the cornerstone of treatment in IIM, and the benefit of additional immunosuppressors is still debated. A limited number of controlled clinical trials have been available to support treatment guidelines, but in the last year, several clinical trials have been publishe...

B linding refers to the concealment of group allocation from one or more individuals involved in a clinical research study, most commonly a randomized controlled trial (RCT). Although randomization minimizes differences between treatment groups at the outset of the trial, it does nothing to prevent differential treatment of the groups later in the trial or the differential assessment of outcome...

BACKGROUND Physicians often administer corticosteroids for the treatment of fluid and vasoactive infusion dependent pediatric shock. This use of corticosteroids is controversial, however, and has never been studied in a pediatric randomized controlled trial (RCT). This pilot trial will determine the feasibility of a larger RCT on the role of corticosteroids in pediatric shock. METHODS/DESIGN ...

BACKGROUND AND PURPOSE Hip resurfacing arthroplasty is claimed to allow higher activity levels and to give better quality of life than total hip arthroplasty. In this literature review, we assessed the therapeutic value of hip resurfacing arthroplasty as measured by functional outcome. METHODS An extensive literature search was performed using the PubMed, Embase, and Cochrane databases. RES...

background: acute pain is common after arthroscopic surgeries and it is one of the most important causes of patient dissatisfaction, admission time and increased morbidity . gabapentin with anti-hyperalgesic effects can play a critical role in pre-emptive analgesia methods. the aim of this study was to assess the efficacy of gabapentin in pain management after surgery and the rate of drug consu...

background: noise-induced hearing loss (nihl) is one of the most common occupational diseases and the second most common cause of workers' claims for occupational injuries. objective: due to high prevalence of nihl and several reports of improper use of hearing protective devices (hpds), we conducted this study to compare the effect of face-to-face training in effective use of earplugs with app...

BACKGROUND Randomized placebo-controlled trials represent the gold standard in evaluating healthcare interventions but are rarely performed within orthopedics. Ethical concerns or well-known challenges in recruiting patients for surgical trials in general have been expressed and adding a placebo component only adds to this complexity. The purpose of this study was to report the challenges of re...

A randomized clinical trial (RCT) noted that sonographic examination in the third trimester, in conjunction with delivery at term for abnormalities of fetal growth, significantly decreased the likelihood of small-for-gestational-age (SGA) neonates in uncomplicated pregnancies. We identified 15 characteristics of screening tests and attempted to determine if there is evidence to routinely obtain...

Background: COVID-19 is a common problem in global health. disease that infects the respiratory tract caused by Coronavirus virus. Symptoms range from mild to severe and life-threatening pneumonia can occur. At beginning of PSBB, information circulated Ivemectin could treat infections. Ivermectin an antiparasitic drug be used as prophylaxis therapy for coronavirus 2019. alternative because ther...