3-hydroxy-3-methylglutaryl-coa reductase inhibitors (statins), are effective serum cholesterol-lowering agents which also have anti-inflammatory properties. the objective of this study was to evaluate the effect of atorvastatin on bronchial hyperresponsiveness. adult patients (age 14 to 65 years) with bronchial hyperresponsiveness (bhr) diagnosis based on the spirometry with methacholine challe...

conclusions decreases in the serum levels of liver aminotransferases and cytokines, in both groups, are related to low-calorie diets and exercise, rather than ptx. results the serum levels of liver aminotransferases were significantly reduced at 3 months and at 6 months, compared with baseline, in both groups. the serum levels of il-6 were significantly decreased, in both groups, only at 6 mont...

background thyroid dysfunction is the second most common endocrine disease in females of reproductive age. there are controversial data on the adverse effect of subclinical thyroid dysfunctions on adverse feto-maternal outcomes. objectives the current study aimed to identify the prevalence of thyroid dysfunction during pregnancy and to assess the effectiveness of treatment with levothyroxine on...

Many clinical trials of uncommon diseases are underpowered because of the difficulty of recruiting adequate numbers of subjects. We propose a clinical trial design with improved statistical power compared to the traditional randomized trial for use in clinical trials of rare diseases. The three-stage clinical trial design consists of an initial randomized placebo-controlled stage, a randomized ...

Comparing the Effect of Different Doses Vitamin D Supplementation During Pregnancy on Prevention Adverse Outcomes; a Randomized Clinical Trial

considering the importance of randomized clinical trials (rcts) in the evidence-based approach, the objective of this study was critical appraisal of reporting rcts in iranian dental journals.after adequate searching, 113 rct articles published during 2003-2010 were reviewed for quality of reporting with the consort scale. the quality of each paper was assessed on 20.although statistical analys...

purpose: to determine the effect of intravitreal bevacizumab (ivb) on neovascular glaucoma (nvg) in terms of intraocular pressure (iop), iris neovascularization (nvi) and best-corrected visual acuity (bcva). methods: in this randomized controlled trial, 26 eyes of 26 patients with nvg receiving conventional treatment were randomly allocated to three 2.5 mg ivb injections at 4-week intervals or ...

background one of the strategies for a good outcome and pain free childbearing is to design the delivery room. objectives the aim of this study was to evaluate the effects of snoezelen room on childbearing outcome such as pain intensity, duration of labor, and perinea status in nulliparous women. patients and methods this study was a randomized controlled clinical trial consists of 100 childbea...

background: observational studies, rather than randomized trials, revealed that statins might be associated with other benefits. objectives: the present study aimed at evaluating the preventive effects of lovastatin when used as a prophylactic agent for early and late infective complications after surgery. patients and methods: a total of 149 patients undergoing elective intracranial and spinal...