Triggered by the explosion of mobile traffic, 5G cellular network requires evolution to increase the system rate 1000 times higher than the current systems in 10 years. Motivated by this common problem, this paper studies to integrate mm-wave access into current cellular networks as multi-band heterogeneous networks to exploit the ultrawideband aspect of the mm-wave band. This paper provides co...

The small GTPase Ran orchestrates pleiotropic cellular responses of nucleo-cytoplasmic shuttling, mitosis and subcellular trafficking, but whether deregulation of these pathways contributes to disease pathogenesis has remained elusive. Here, we generated transgenic mice expressing wild type (WT) Ran, loss-of-function Ran T24N mutant or constitutively active Ran G19V mutant in pancreatic islet β...

C3H/HeJ inbred mice are defective in that they are highly resistant to endotoxic shock as compared with normal responder mice. Their B cells and macrophages do not respond significantly when exposed to lipopolysaccharide (LPS), whereas cells from the responder mice do. Using a functional assay, we previously isolated a cDNA, which encodes for Ran/TC4 GTPase. We now show that this gene is mutate...

The Ran GTPase plays a key role in nucleocytoplasmic transport. In its GTP-bound form, it directly interacts with members of the importin beta family of nuclear transport receptors and modulates their association with cargo. Work in cell-free higher-eukaryote systems has demonstrated additional roles for Ran in spindle and nuclear envelope formation during mitosis. However, until recently, no R...

Abstract RAN (Rapid Automatized Naming) is known to be a robust predictor of reading development in different languages. Much less about predictive power bilingual contexts. This the first meta-analysis research with children, assessing strength RAN-reading relationship both within and across It also explored moderators that may affect this relationship. The search identified 38 published studi...

Huntington disease (HD) is caused by a CAG ⋅ CTG expansion in the huntingtin (HTT) gene. While most research has focused on the HTT polyGln-expansion protein, we demonstrate that four additional, novel, homopolymeric expansion proteins (polyAla, polySer, polyLeu, and polyCys) accumulate in HD human brains. These sense and antisense repeat-associated non-ATG (RAN) translation proteins accumulate...

The small guanosine triphosphatase Ran is loaded with guanosine triphosphate (GTP) by the chromatin-bound guanine nucleotide exchange factor RCC1 and releases import cargoes in the nucleus during interphase. In mitosis, Ran-GTP promotes spindle assembly around chromosomes by locally discharging cargoes that regulate microtubule dynamics and organization. We used fluorescence resonance energy tr...

The next generation access networks in UMTS and CDMA networks are expected to be IP-based Radio Access Networks (RAN). There are several benefits of IP-based RAN including lower costs, flexibility of merging wired and wireless networks, network scalability and reliability. In addition to the quality of service issues in IP-based RAN, the issue of connectivity and assignment of calls to radio ne...