In the present investigation, soil samples were collected from 10 villages belonging to Pathankot district, Punjab, India and assessed for radium content using LR-115 plastic detector. The ‘track etch’ technique has been employed for measuring the radium content. From the radium content, radon exhalation rates and mass exhalation rates were calculated for these samples. The mass exhalation rate...

BACKGROUND Bone metastases are associated with increased morbidity and poor prognosis in breast cancer patients. Radium-223 dichloride is a calcium mimetic that localizes to bone, providing targeted therapy for skeletal metastasis. METHODS We investigated the mode of action of radium-223 dichloride using breast cancer cell, osteoclast, and osteoblast cultures as well as a mouse model of breas...

BACKGROUND The treatment of metastatic castration-resistant prostate cancer has changed with the introduction of radium-223, cabazitaxel, abiraterone and enzalutamide. To assess value for money, their cost effectiveness in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel from the Dutch societal perspective was investigated. METHODS A cost-effecti...

Purpose: Radium-223 dichloride (radium-223, Xofigo), a targeted alpha therapy, is currently used for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone metastases. This study examines the mode-of-action and antitumor efficacy of radium-223 in two prostate cancer xenograft models.Experimental Design: Mice bearing intratibial LNCaP or LuCaP 58 tumors were randomi...

This article discusses bone as a source of lead to the rest of the body and as a record of past lead exposure. Bone lead levels generally increase with age at rates dependent on the skeletal site and lead exposure. After occupational exposure, the slow decline in blood lead, a 5- to 19-year half-life, reflects the long skeletal half-life. Repeated measurements of bone lead demonstrate the slow ...

Submarine groundwater discharge (SGD) into the coastal zone has received increased attention in the last few years as it is now recognized that this process represents an important pathway for material transport. Assessing these material fluxes is difficult, as there is no simple means to gauge the water flux. To meet this challenge, we have explored the use of a continuous radon monitor to mea...

Radium-based estimates of cesium isotope transport and total direct ocean discharges from the Fukushima Nuclear Power Plant accident M. A. Charette, C. F. Breier, P. B. Henderson, S. M. Pike, I. I. Rypina, S. R. Jayne, and K. O. Buesseler Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA Department of Physical Oceanography, Woods Ho...

The uranium (234U/238U) and radium (228Ra/226Ra) activity ratios and 87Sr/86Sr isotopic ratio in thermal groundwater, subsurface water (groundwater) and river water from Poddebice and Uniejow were determined. The uranium and radium activity ratios and strontium isotopic ratio varied from 0.629 to 1.471, from 0.396 to 4.961 and from 0.708438 to 0.710344, respectively. The results for the thermal...

Numerous studies have used naturally occurring Ra isotopes (223Ra, 224Ra, 226Ra, and 228Ra, with half-lives of 11.4 d, 3.7 d, 1600 y, and 5.8 y, respectively) to quantify water mass ages, coastal ocean mixing rates, and submarine groundwater discharge (SGD). Using Monte Carlo models, this study investigated how uncertainties in Ra isotope activities and the derived activity ratios (AR) arising ...

The Naturally Occurring Radioactive Materials (NORMs) that are potentially generated from oil and gas extractions in Albania have been disposed of without regulations for many decades, and therefore, an extensive survey in one of the most productive regions (Vlora-Elbasan) was performed. A total of 52 gamma ray spectrometry measurements of soil, oil-sand, sludge, produced water and crude oil sa...