INTRODUCTION The purpose of this study was to investigate the safety and efficacy of CyberKnife (CK) robotic radiosurgery for treatment of adrenal metastases. METHODS We performed a retrospective analysis of 23 patients with adrenal metastases who had been treated with CK between October 2006 and December 2015. Fifteen patients received chemotherapy prior to radiosurgery, all patients underwe...

Treatment of recurrent glioblastoma is still challenging. Stereotactic radiosurgery has been accepted as a treatment option for recurrent glioblastoma after standard chemotherapy and irradiation. However, the efficacy of stereotactic radiosurgery at recurrence has been limited, mainly due to the highly infiltrative nature of the tumor which makes the lesion difficult to define as the target. To...

BACKGROUND Conventional external beam radiotherapy is a standard procedure for treatment of spinal metastases. In case of progression spinal cord tolerance limits further radiotherapy in pre-irradiated areas. Spinal stereotactic radiotherapy is a non-invasive option to re-treat pre-irradiated patients. Nevertheless, spinal radiosurgery results in relevant dose deposition within the myelon with ...

Stereotactic radiosurgery, including gamma knife radiosurgery (GKS), can in rare cases result in de novo cavernous malformations (CMs). Here, we present a case of de novo CM induced by GKS following treatment of a cerebellar arteriovenous malformation (AVM). A 48-year-old woman was diagnosed with left unilateral Moyamoya disease. Conventional cerebral angiography also revealed an AVM in the lef...

BACKGROUND The glomus jugulare tumor is a slowly growing benign neoplasm originating from neural crest. There is a high morbidity associated with surgical resection of glomus jugulare. Radiosurgery play a relevant role as a therapeutic option in these tumors and its use has grown in popularity. The authors describe a retrospective series of 15 patients and reviewed the literature about the glom...

Treatment of arteriovenous malformations (AVMs) is complicated because of many factors including increasing size, eloquent location, and risk of unacceptable neurological deficits. Each of the treatment modalities, microsurgery, embolization, and stereotactic radiosurgery (SRS), has its pros and cons. Surgery and embolization are limited by location, size, and afferent and efferent vessel anato...

To evaluate the feasibility of using radiosensitivity of peripheral leukocytes as a predictor of clinical therapeutic responses to radiosurgery in individuals with cerebral arteriovenous malformation (AVM), we enrolled 18 patients years after they had received Gamma Knife radiosurgery for their cerebral AVM. The AVMs were shown with different degrees of regression in size in posttherapeutic per...

In the five decades since its introduction as a concept, radiosurgery has been technically refined to the point where it has revolutionized many aspects of treating central nervous system disease.This article reviews the technical basis of stereotactic radiosurgery as well as the radiobiologic principles underlying its use.

Citation: Kunos CA (2016) Commentary: Phase I Trial of Carboplatin and Gemcitabine Chemotherapy and Stereotactic Ablative Radiosurgery for the Palliative Treatment of Persistent or Recurrent Gynecologic Cancer. Front. Oncol. 6:263. doi: 10.3389/fonc.2016.00263 Commentary: Phase I trial of Carboplatin and Gemcitabine Chemotherapy and Stereotactic ablative radiosurgery for the Palliative treatmen...