نتایج جستجو برای: radioprotective

تعداد نتایج: 1071  

Journal: :Al-Azhar Journal of Pharmaceutical Sciences 2019

H. Mozdarani, M. Mahdavi,

Background: Radioprotective effect of famotidine was previously shown on radiation induced micronuclei and chromosomal aberrations in human peripheral lymphocytes and mouse bone marrow cells however, its radioprotective property has never been studied in mouse spermatogenesis. It was also shown that vitamin C as an antioxidant also exert its radioprotective effect on many biological s...

A. Kebriaeezadeh, A. Khalaj, A.R. Barazesh, D. Beiki, H. Esmaeili, M. Pirali Hamedani, S.J. Hosseinimehr, Sh. Akhlaghpoor,

Background: The aim of this study was to evaluate the radioprotective capacity of some novel aminoalkylated dithiocarbamic acid potassium salts against γ-irradiation in mice. Materials and Methods: Eight compounds containing 2-aminoethyl-, 3- aminopropyl-, 4-aminobutyl-, 5-aminopentyl-, 6- aminohexyl-, 7-aminoheptyl-, 8-aminooctyl and 9- aminononyl of dithiocarbamate derivatives were prepared. ...

Journal: :Journal of Cancer Research and Therapeutics 2010

2017
A.H. Heidari A. Shabestani Monfared H. Mozdarani A. Mahmoudzadeh A. Razzaghdoust

Background We intend to study the inhibitory effect of sulfur compound in Ramsar hot spring mineral on tumor-genesis ability of high natural background radiation. Objective The radioprotective effect of sulfur compounds was previously shown on radiation-induced chromosomal aberration, micronuclei in mouse bone marrow cells and human peripheral lymphocyte. Ramsar is known for having the highes...

Journal: :Blood 1995
Y Kalechman A Zuloff M Albeck G Strassmann B Sredni

The immunomodulator ammonium trichloro(dioxyethylene-0-0')tellurate (AS101) has previously been found by us to have radioprotective properties when injected into mice before sublethal and lethal doses of irradiation. AS101 also was found to protect mice from hematopoietic damage caused by various chemotherapeutic drugs. Based on these findings, phase II clinical trials with cancer patients trea...

2015
Megan E. Crowe Christopher J. Lieven Alex F. Thompson Nader Sheibani Leonard A. Levin

Exposure to radiation can damage endothelial cells in the irradiated area via the production of reactive oxygen species. We synthesized phosphine-borane complexes that reduce disulfide bonds and had previously been shown to interfere with redox-mediated signaling of cell death. We hypothesized that this class of drugs could interfere with the downstream effects of oxidative stress after irradia...

2010
Aaron P Brown Eun Joo Chung Mary Ellen Urick William P Shield Anastasia L Sowers Angela Thetford Uma T Shankavaram James B Mitchell Deborah E Citrin

BACKGROUND Fullerene compounds are known to possess antioxidant properties, a common property of chemical radioprotectors. DF-1 is a dendrofullerene nanoparticle with antioxidant properties previously found to be radioprotective in a zebrafish model. The purpose of this study was to evaluate the radioprotective effects of DF-1 in a murine model of lethal total body irradiation and to assess for...

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