The use of monoclonal antibodies to deliver radioisotopes directly to tumor cells has become a promising strategy to enhance the antitumor effects of native antibodies. Since the and -particles emitted during the decay of radioisotopes differ in significant ways, proper selection of isotope and antibody combinations is crucial to making radioimmunotherapy a standard therapeutic modality. Becaus...

Positron emission tomography in conjunction with radiopharmaceuticals labeled with positron emitting radionuclides opens the possibility of visualizing in vivo in an atraumatic way fundamental parameters of metabolism in man. The main positron emitting radioisotopes carbon-II, oxygen-IS, nitrogen-13 and fluorine-IR used for labeling radiopharmaceuticals (sugars, aminoacids, fatty acids and drug...

The Naval Civil Engineering Laboratory has conducted a study of the potential applications of isotopic devices and techniques within the Naval Shore Establishment. Radiation characteristics, general applications of isotopic devices, and specific problem areas are discussed. Recommendations are included for the use of surface density and moisture gages in the inspection of compacted earth, and f...

The use of neutrons for cargo interrogation has the potential to drastically improve threat detection. Previous research has focussed on the production of (24)Na, based on the isotopes produced in pharmaceuticals and medical devices. For both the total activity and the ingestion dose we show that a variety of isotopes contribute and that (24)Na is only dominant under certain conditions. The com...