control group (radiation only). A & B: CT scans with radiation treatment planning superimposed. Area in red received full radiation dose (3x11Gy). All animals received radiation in same location. C & D: CT scans at 8 weeks post radiation. While lung in C has homogeneous tissue density, the lung in D shows an area of hypodensity that correlates with the irradiated area (oval and arrow). E & F: c...

OBJECTIVE A second lung cancer is occasionally observed in patients who underwent surgical resection of the index lung cancer. The purpose of this study is to evaluate stereotactic body radiation therapy for second lung cancer. METHODS Fifty-one medically inoperable patients who underwent stereotactic body radiation therapy for second lung cancer were the subjects: 31 cases of multiple primar...

Lung cancer is managed using conventional therapies, including chemotherapy, radiation therapy, or a combination of both. Each these therapies has its own limitations, such as the indiscriminate killing normal well cells, solubility chemotherapeutic drugs, rapid clearance drugs from circulation before reaching tumor site, resistance cells to radiation, and over-sensitization radiation. Other tr...

Radiation therapy is an important therapeutic modality for thoracic malignancies. However, radiation-induced pulmonary injuries such as radiation pneumonitis and fibrosis are major dose-limiting factors. Previous research shows that micro-computed tomography (micro-CT) can detect radiation-induced lung injuries a few months following irradiation, but studies to assess the early response of lung...

Extra renal extra cranial malignant rhobdoid tumors (MRT) are rare, frequently lethal and affect mostly children. No definite treatment has been made and the role of radiation therapy is poorly defined. This report explains a 14 year old girl with MRT in her neck soft tissue. She is alive with no evidence of disease 18 months after diagnosis. Through the experience with this case, we suggested...

Introduction: Proton therapy is newer therapeutic method for early stage breast cancer. Proton beams release most of their energy in the Bragg peak and then will be a rapid decline in their end. When protons interact with matter, produce secondary particles like neutrons and gammas, and these unwanted radiation has no beneficial effect and also is believed to increase the risk ...

Lung function depends on the expansion and contraction of lung tissue during the respiratory cycle. The measurement of regional pulmonary function is of great interest and importance since many lung diseases can cause changes in biomechanical or material properties. It is also significant to study the radiation-induced changes in pulmonary function following radiation therapy. In this thesis, w...