OBJECTIVES Proton pump inhibitors (PPIs) are among the most prescribed medications worldwide, however, there is growing concern regarding potential negative effects on bone health. The aim was to examine the effect of dose and type of PPI use on subsequent use of osteoporosis medication and fractures in older Australian women. METHODS Data were included from 4432 participants (born 1921-26) i...

The asymmetric unit of the title compound, C(8)H(5)F(3)N(2), consists of two half-mol-ecules, one lies on a mirror plane and the other is generated by twofold rotation symmetry, with the axis running through the trifluoro-methyl C atom and the attached benzimidazole C atom. The two 2-trifluoro-methyl-1H-benzimidazole mol-ecules are connected by N-H⋯N hydrogen bonds involving the disordered NH H...

Microspheres can be tailored to provide targeted and/or sustained release in different parts of the body, including those of eye, nasal cavity, urinary, colon and gastrointestinal tract, thus offering the possibilities of localized as well as systemic controlled release of drugs. Prolonged release of drugs and a reduction in frequency of drug administration can highly improve the patient compli...

A new method was developed to identify nonpeptidic metalloproteinase inhibitors with novel zinc binding groups. Application of this method to matrix metalloproteinase-9 resulted in the identification of aminomethyl benzimidazole analogue 7a with an IC(50)=13 microM.

The Medical Journal of Australia ISSN: 0025729X 7 March 2005 182 5 235-236 ©The Medical Journal of Australia 2005 www.mja.com.au Lessons from practice nephritis induced by esomeprazole, along with six renal failure and two of renal impairment. In October 2004, the manufacturer of esomep Zeneca, reported being aware of at least 15 cases acute interstitial nephritis possibly induced by esom at le...

Two simple, rapid and accurate conductometric methods were developed for determination of losartan potassium, pantoprazole sodium, sumatriptan succinate, rabeprazole sodium and lomefloxacine HCl in pure form as well as in their pharmaceutical formulations. The proposed methods based on using two different precipitating agents for conductometric determination of the cited drugs. Method (A) based...

Article history: Received on: 17/06/2016 Revised on: 24/07/2016 Accepted on: 04/08/2016 Available online: 26/09/2016 Proton pump inhibitors (PPIs) are the most widely prescribed class of gastrointestinal drugs as they have minimal side effects and few significant drug interactions, and are generally considered safe for long-term treatment. The proton pump inhibitors such as omeprazole, esomepra...

Epidemiological, endoscopic and pathophysiological studies confirm the relationship between obesity gastroesophageal reflux disease (GERD) is characterized by a more severe course, has clinical features. In treatment of GERD, it necessary to use an individualized integrated approach, which consists in combined diet therapy, lifestyle changes drug therapy. The basis pharmacotherapy for GERD are ...

Rabeprazole sodium is a proton pump inhibitor, used in acid-related disorders, like peptic ulcers and gastroesophageal reflux. It is known to be an acid-labile drug, however, few data about its stability under other factors are available. The aim of this work was to study the photodegradation of rabeprazole, to determine its kinetics and to elucidate the structures of the main degradation produ...