P-glycoprotein (Pgp) exports hundreds of chemically unrelated, hydrophobic compounds out cells. Since Pgp can greatly affect bioavailability, pharmacokinetics and efficacy therapeutic drugs, there is great interest in understanding the mechanism by which drugs are extruded. an ABC transporter with two nucleotide binding domains (NBDs) that bind hydrolyze ATP, leading to extensive conformational...

Introducing an H-Hopf algebroid structure into Uq,p(ŝl2), we investigate the vertex operators of the elliptic quantum group Uq,p(ŝl2) defined as intertwining operators of infinite dimensional Uq,p(ŝl2)-modules. We show that the vertex operators coincide with the previous results obtained indirectly by using the quasi-Hopf algebra Bq,λ(ŝl2). This shows a consistency of our H-Hopf algebroid struc...

The QR algorithm is one of the three phases in process computing eigenvalues and eigenvectors a dense nonsymmetric matrix. This paper describes task-based for reducing an upper Hessenberg matrix to real Schur form. also supports generalized eigenvalue problems (QZ algorithm) but this concentrates on standard case. adopts previous algorithmic improvements, such as tightly-coupled multi-shifts Ag...

We report the results of resonant magnetic XUV reflectivity experiments performed at the XUV free-electron laser FERMI. Circularly polarized XUV light with the photon energy tuned to the Fe M2,3 edge is used to measure resonant magnetic reflectivities and the corresponding Q-resolved asymmetry of a Permalloy/Ta/Permalloy trilayer film. The asymmetry exhibits ultrafast changes on 240 fs time sca...

Surface-induced atomic layering in liquid gallium has been observed using x-ray reflectivity, ultrahigh vacuum conditions, and sputtered clean surfaces. Reflectivity data, collected on a supercooled liquid sample to momentum transfers as large as qz ­ 3.0 Å21, exhibit a strong maximum near 2.4 Å21 indicating a layer spacing that is comparable to its atomic dimensions. The amplitude of the elect...

The surface normal structure of the mercury liquid-vapor interface has been investigated by measuring the x-ray reflectivity out to a momentum transfer of qz ­ 2.5 Å . The results provide direct experimental proof of surface layering in liquid metals. The layer spacing is given by the atomic dimensions of the Hg atoms. The minimum layer width agrees well with the predictions of capillary wave t...

If x, )...) X, are independent identically distributed Rd-valued random vectors with probability measure p and empirical probability measure p,, and if QZ is a subset of the Bore1 sets on Rd, then we show that P{sup,,~ IF,@) -,u(A)( > E) < cs(Q, n*) eCZnr2, where c is an explicitly given constant, and s(W, n) is the maximum over all (x, ,..., XJ E Rd” of the number of different sets in {lx , ,....

BACKGROUND PubChem provides a 3-D neighboring relationship, which involves finding the maximal shape overlap between two static compound 3-D conformations, a computationally intensive step. It is highly desirable to avoid this overlap computation, especially if it can be determined with certainty that a conformer pair cannot meet the criteria to be a 3-D neighbor. As such, PubChem employs a ser...