Lipid particles of the yeast Saccharomyces cerevisiae are storage compartments for triacylglycerols (TAG) and steryl esters (STE). Four gene products, namely the TAG synthases Dga1p and Lro1p, and the STE synthases Are1p and Are2p contribute to storage lipid synthesis. A yeast strain lacking the four respective genes is devoid of lipid particles thus providing a valuable tool to study the physi...

BACKGROUND The <80 % Helicobacter pylori eradication rate with sequential therapy is unsatisfactory. Modified bismuth quadruple therapy, replacing metronidazole with amoxicillin, could be promising because H. pylori resistance to tetracycline or to amoxicillin is relatively low. A 14-day modified bismuth quadruple protocol as first-line H. pylori treatment was compared with 10-day sequential th...

We show here that quadruple lenses can be useful laboratories to probe whether the potential of the lensing galaxy is purely elliptical or whether an additional distortion is present in the deflector plane. For this test we only have to know the relative image positions of the quadruple lens system and the (relative) center of light position of the lensing galaxy. Furthermore we introduce new m...

BACKGROUND Due to increasing antimicrobial resistance, a bismuth-based quadruple regimen has been recommended as an alternative first-line therapy for Helicobacter pylori (H pylori) eradication. However, different results are varied greatly and the availability of bismuth was limited in some countries. We assessed the efficacy and safety of 14-day berberine-containing quadruple therapy as an al...

BACKGROUND The use of quadruple therapy for Helicobacter pylori (H. pylori) eradication is a highly efficacious, gold standard regimen. However, according to a number of studies, this regimen has numerous compliance problems and adverse effects. In the current study we have evaluated the H. pylori eradication rate following a quadruple therapy that included omeprazole, bismuth subcitrate, amoxi...

Background\Aim: Quadruple daily administration of proton-pump inhibitor (PPI) therapy achieves potent acid inhibition, and combined with amoxicillin, with its pharmacodynamic and pharmacokinetic characteristics, may be efficient for Helicobacter pylori eradication. We compared the efficacy of two optimized high-dose dual therapies with a bismuth-containing quadruple regimen for treating H. pylo...

Apollonian circle packings arise by repeatedly filling the interstices between mutually tangent circles with further tangent circles. It is possible for every circle in such a packing to have integer radius of curvature, and we call such a packing an integral Apollonian circle packing. This paper studies number-theoretic properties of the set of integer curvatures appearing in such packings. Ea...

AIM To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication failure. METHODS This study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between January 2005 and December 2015. We retrospectively demonstrated H. pylori era...

When floating point arithmetic is used in numerical computation, cancellation of significant digits, round-off errors and information loss cannot be avoided. In some cases it becomes necessary to use multiple precision arithmetic; however some operations of this arithmetic are difficult to implement within conventional computing environments. In this paper we consider implementation of a quadru...

In this paper, we show that there does not exist a quadruple of positive integers a1 < a2 < a3 < a4 such that aiaj + 1 (i 6= j) are all members of the Tribonacci sequence (Tn)n≥0.