BACKGROUND Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway. METHODS We examined the expression of TWIST, E-cadherin, hypoxia-inducible factor 1α (HIF1α), and p53 by immunohistochemistry in 123 cases of ovarian epithelial c...

Evidence suggests that over-expression of TWIST, an epithelial-mesenchymal transition inducer, might have a correlation with cancer progression and chemoresistance. However, its roles in radioresistance of cancer have rarely been reported. High TWIST expression was detected in nasopharyngeal carcinoma (NPC) and associated with poor prognosis. Thus, in the present study, we aimed to determine wh...

ab initio calculations at hf/6-31g* level of theory for geometry optimization and mp2/6-31g*//hf/6-31g* for a single point total energy calculation are reported for the importantenergy-minimum conformations and transition-state geometries of 1, 3-diazacyclohepta-1, 2-diene (2) and 1, 3-diazacycloocta-1, 2-diene (3). the c2 symmetric twist-chair (2-tc)conformation of 2 is calculated to be 7.4 kj...

The hyperelliptic curve cryptosystems take most of the time for computing a scalar multiplication kD of an element D in the Jacobian JC of a hyperelliptic curve C for an integer k. Therefore its efficiency depends on the scalar multiplications. Among the fast scalar multiplication methods, there is a method using a Frobenius map. It uses a Jacobian defined over an extension field of the definit...

Let f be a modular form of even weight on 0 (N) with associated motive M f . Let K be a quadratic imaginary eld satisfying certain standard conditions. We improve a result of Nekov a r and prove that if a rational prime p is outside a nite set of primes depending only on the form f , and if the image of the Heegner cycle associated with K in the p-adic intermediate Jacobian of M f is not divisi...

Consider the elliptic curves given by En,θ : y 2 = x + 2snx − (r − s)nx where 0 < θ < π, cos(θ) = s/r is rational with 0 ≤ |s| < r and gcd(r, s) = 1. These elliptic curves are related to the θ-congruent number problem as a generalization of the congruent number problem. For xed θ this family corresponds to the quadratic twist by n of the curve Eθ : y 2 = x +2sx − (r − s)x. We study two special ...

Let p be a prime and K a number field of degree p. We count the number of elliptic curves, up to K-isomorphism, having a prescribed property, where this property is either that the curve contains a fixed torsion group as a subgroup, or that it has an isogeny of prescribed degree. We also study the following question: for a given n such that |Y0(n)(Q)| > 0, does every elliptic curve over K with ...

Medaka twist, a basic helix-loop-helix (bHLH) transcription factor, is expressed in the sclerotome during embryogenesis. We previously established a line of twist-EGFP transgenic medaka, whose EGFP expression is regulated by the twist promoter; therefore, we could observe the behavior of sclerotomal cells in vivo. In the transgenic medaka embryos, EGFP-positive sclerotomal cells migrated dorsal...

This study aimed to examine HIF-2α, TWIST, and CXCR4 expression in papillary thyroid carcinoma (PTC) and assesses the association of their expression with clinicopathological indicators. HIF-2α, TWIST, and CXCR4 protein expression in 129 PTCs, 61 nodular hyperplasia, and 118 normal thyroid tissue specimens was analyzed using immunohistochemistry. The protein expression levels of these three mol...

We present a higher-twist production mechanism for η c and χ J charmonium at large momentum fraction x F in pion-nucleon collisions. The higher-twist contribution is essentially independent of x F and therefore becomes dominant at large x F , where the leading-twist contribution falls off as (1 − x F) 3. We show that the higher-twist mechanism produces longitudinally polarized χ 1 and χ 2. For ...