Sandia National Laboratories has found that the reliability and failure modes of current-generation network technologies can be effectively modeled using fault treebased probabilistic logic modeling {PLM) techniques. We have developed fault tree models that include various hierarchical networking technologies and classes of components interconnected in a wide variety of typical and atypical con...

This paper presents a methodology for quantitative risk analysis on oil and gas production platforms that incorporates both technical and operational conditions. The basic building blocks of the methodology are barrier block diagrams, event trees, fault trees, and influence diagrams. Barrier block diagrams are used to illustrate the event scenarios and the effect of barrier systems on the scena...

A viable means of CO2 reduction in the atmosphere is to capture and concentrate CO2 from large point sources such as power plants and petroleum refineries and store it by underground injection. The main concern for commercial scale CO2 sequestration in geologic formations is the uncertainties associated with this process. The risks involved in different stages of a CO2 sequestration project are...

The purpose of present article is to discuss the concept of pharmaceutical Quality by Design (QbD) and describe how it can be help to ensure pharmaceutical quality. Quality by design is an essential part of the modern approach to pharmaceutical quality. The elements of quality by design are examined and a consistent nomenclature for quality by design, critical quality attribute, critical proces...