نتایج جستجو برای: pyruvate dehydrogenase kinase 4 endurance training metabolic flexibility estrogen

تعداد نتایج: 2123275  

Journal: :The Biochemical journal 1969
L V Eggleston H A Krebs

1. The activities of four enzymes of glycolysis were assayed in the liver of five different strains of rats (four ;Wistar-derived', one Sprague-Dawley) kept on three different but very similar diets. 2. Major strain differences were found for the activities of pyruvate kinase (3-fold), alpha-glycerophosphate dehydrogenase (5-fold), glyceraldehyde phosphate dehydrogenase (3-fold) and triokinase ...

Journal: :The Biochemical journal 2014
Minako Imamura Benny Hung-Junn Chang Motoyuki Kohjima Ming Li Byounghoon Hwang Heinrich Taegtmeyer Robert A Harris Lawrence Chan

MondoA is a basic helix-loop-helix (bHLH)/leucine zipper (ZIP) transcription factor that is expressed predominantly in skeletal muscle. Studies in vitro suggest that the Max-like protein X (MondoA:Mlx) heterodimer senses the intracellular energy status and directly targets the promoter region of thioredoxin interacting protein (Txnip) and possibly glycolytic enzymes. We generated MondoA-inactiv...

Journal: :Circulation. Heart failure 2015
Andrew N Carley Domenico M Taglieri Jian Bi R John Solaro E Douglas Lewandowski

BACKGROUND The failing heart displays increased glycolytic flux that is not matched by a commensurate increase in glucose oxidation. This mismatch induces increased anaplerotic flux and inefficient glucose metabolism. We previously found adult transgenic mouse hearts expressing the fetal troponin I isoform, (ssTnI) to be protected from ischemia by increased glycolysis. In this study, we investi...

Journal: :Cell 2008
Vihang A. Narkar Michael Downes Ruth T. Yu Emi Embler Yong-Xu Wang Ester Banayo Maria M. Mihaylova Michael C. Nelson Yuhua Zou Henry Juguilon Heonjoong Kang Reuben J. Shaw Ronald M. Evans

The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. Although certain natural compounds, such as reseveratrol, have endurance-enhancing activities, their exact metabolic targets remain elusive. We therefore tested the effect of pathway-specific drugs on enduranc...

2002
Richard L. Cate Thomas E. Roche

We have presented evidence that stimulation of pyruvate dehydrogenase, (PDH.) kinase activity by pyruvate or by acetyl-CoA is mediated through acetylation of lipoyl moieties (Cate, R. L., and Roche, T. E. (1978) J. Biol. Chem. 253,496-503). In accord with this indirect mechanism for the action of these effecters, we now find that the degree of stimulation of PDH, kinase increases with the level...

2013
Gopinath Sutendra Evangelos D. Michelakis

Current drug development in oncology is non-selective as it typically focuses on pathways essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is characterized by increased glycolysis and suppressed mitochondrial glucose oxidation (GO) provides cancer cells with a proliferative advantage, conducive with apoptosis resistance and even increased angiogene...

Journal: :Diabetes 1980
F L Kiechle L Jarett D A Popp N Kotagal

Insulin treatment of adipocytes increased the amount or activity of a low molecular weight, acid-stable material which, when isolated from intact adipocytes by heat extraction and subsequent Sephadex G25 chromatography, yielded a single active fraction that stimulated mitochondrial pyruvate dehydrogenase by activating the phosphatase and not by altering the kinase activity. Phosphatase activati...

Journal: :The Journal of biological chemistry 1991
M J MacDonald J H Kaysen S M Moran C E Pomije

It has been shown previously that glucose-induced insulin release is completely absent in rat pancreatic islets that had been cultured for 1 day at low glucose (1 mM) and that it is restored by culturing islets for a 2nd day at high (20 mM) glucose (MacDonald, M. J., Fahien, L. A., McKenzie, D. I., and Moran, S. M. (1991) Am. J. Physiol. 259, E548-E554). It has been suggested that the incapacit...

Journal: :The Biochemical journal 2001
E Kolobova A Tuganova I Boulatnikov K M Popov

The enzymic activity of the mammalian pyruvate dehydrogenase complex is regulated by the phosphorylation of three serine residues (sites 1, 2 and 3) located on the E1 component of the complex. Here we report that the four isoenzymes of protein kinase responsible for the phosphorylation and inactivation of pyruvate dehydrogenase (PDK1, PDK2, PDK3 and PDK4) differ in their abilities to phosphoryl...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Caroline Guglielmetti Chloé Najac Alessandro Didonna Annemie Van der Linden Sabrina M Ronen Myriam M Chaumeil

Proinflammatory mononuclear phagocytes (MPs) play a crucial role in the progression of multiple sclerosis (MS) and other neurodegenerative diseases. Despite advances in neuroimaging, there are currently limited available methods enabling noninvasive detection of MPs in vivo. Interestingly, upon activation and subsequent differentiation toward a proinflammatory phenotype MPs undergo metabolic re...

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