A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5'-O-tritylated and the 5'-O-dimethoxytritylated 5-fluorouri...

A cost-effective and environmentally benign benzopyrano-pyrimidine derivative synthesis has been established with the condensation of different salicylaldehyde derivatives, piperidine/morpholine malononitrile, in presence a catalyst containing p-toluene sulphonic acid (PTSA) at 80 °C temperature. This procedure offers new enriched approach for synthesizing derivatives high yields, straightforwa...

An allele of rpoD (rpoD1181) that results in increased synthesis of the pyrimidine moiety of thiamine in Salmonella enterica was identified. The S508Y substitution caused by rpoD1181 is analogous to the S506F derivative of the Escherichia coli protein. The properties of this E. coli mutant protein have been well characterized in vitro. Identification of a metabolic phenotype caused by the rpoD1...

A high resolution a.c. calorimetric study of a phenyl pyrimidine derivative with one alkyl and one per ̄ uorinated end group shows that the excess heat capacity associated with the smectic A± smectic C transition exhibits critical ̄ uctuation behaviour that is consistent with the three-dimensional XY universality class. This is in contrast to the usual mean-® eld SmA± SmC behaviour and the near t...

Independent 4 A electron density maps calculated for the extracellular nuclease of Staphylococcus aureus (based on data from three heavy-atom derivatives) and for a nuclease-thymidine-3',5'-diphosphate-calcium ion complex (based on a single isomorphous derivative) show about 60 per cent of the chain resolved, including 3(1/2) turns of helix. The pyrimidine ring of the inhibitor fits into a pock...

In this research, the interaction of pyrimidine molecule with pristine B12N12 nanocluster is studied in different phases to understand the effect of environment on the electronic properties of the designated adsorption complexes. To this end, the pyrimidine adsorption over B12N12 in the gas phase and water medium is investigated using density functional theory (DFT) at the B97D/6-31+G(d,p) leve...

It was demonstrated by Richardson in 1936 (1) that uracil and guanine were essential for the growth of certain bacteria. Later several investigators found that purines and pyrimidines and corresponding nucleotides are of importance for the metabolism of different microorganisms. Snell and Mitchell (2) established the fact that guanine, adenine, uracil, and thymine may be limiting factors of gro...