A pyrazolone compound acting as a formyl peptide receptor (FPR) 2/ALX-selective agonist has been reported, but its pharmacological activities on human FPRs (hFPRs) and mouse FPRs (mFprs) have not been well demonstrated. In this study, we found that this compound, designated as compound A, induced concentration-dependent calcium flux not only in Chinese hamster ovary (CHO) cells expressing hFPR2...

New complexes of Al(III), Fe(III), Co(III), Rh(III), In(III) and Zr(IV) with 1-phenyl3-methyl-4-trifluoroacetyl-pyrazolone-5, (HPMTFP), have been synthesized and characterized by means of elemental analyses, conductivity and magnetic moment measurements, proton NMR and infrared spectroscopy. It is concluded that the ligand, HPMTFP, reacts as a bidentate enol forming neutral metal chelates. The ...

Two series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. Two of these compounds showed a high activity against MTB (MIC=4 microg/mL). The newly synthesized pyrazolones were also computationally investigated to analyze if their properties fit the pharmacophoric model for antitubercular ...

Regioselective synthesis of highly functionalized pyranopyrazoles was achieved in excellent yield from phenyl pyrazolone, substituted aromatic aldehyde with nitroketene-N,S-acetal in the presence of indium trichloride as a versatile catalyst under reflux condition in ethanol-water mixture. All reactions preceeded within a short period of time with excellent purity. All of the synthesized compou...

The discharge of effluents from material ventures has been a noteworthy worry of the cutting edge world because of the colossal contamination that these effluents advance on the water assets. Among the engineered colors discharged in effluents from material ventures, azo dyes are a standout amongst the most unfavorable classes since it is exceedingly determined in the oceanic environment, becau...

BACKGROUND Pyrazole and pyrazolone motifs are well known for their wide range of biological activities such as antimicrobial, anti-inflammatory, and antitumor activities. The incorporation of more than one pharmacophore in a single scaffold is a well known approach for the development of more potent drugs. In the present investigation, a series of differently substituted 4-arylidene pyrazole de...