OBJECTIVES To describe deaths in prison among opioid-dependent people, and examine associations between receipt of opioid substitution therapy (OST) and risk of death in prison. DESIGN Retrospective cohort study. SETTING Adult prisons in New South Wales (NSW), Australia. PARTICIPANTS 16 715 opioid-dependent people who were received to prison between 2000 and 2012. INTERVENTIONS Opioid s...

In magnetic random access memory (MRAM) devices, soft magnetic thin film elements such as permalloy (Py) are used as unit cells of information. The epitaxial integration of these elements with the technologically important substrate Si (100) and a thorough understanding of their magnetic properties are critical for CMOS-based magnetic devices. We report on the epitaxial growth of Ni82.5Fe17.5 (...

Pyrolysis-gas chromatography (Py-GC) has become well established as a simple, quick and reliable analytical technique for a range of applications including the analysis of polymeric materials. Recent developments in Py-GC technology and instrumentation include laser pyrolysis and non-discriminating pyrolysis. Progress has also been made in the detection of low-level polymer additives with the u...

The polyoma (PY) viral DNA sequences present in a series of hamster tumor cell lines were evaluated using the blotting technique of Southern ((1975) J. Mol. Biol. 98, 503-517). Remarkably, no cell line contained an intact distal portion of the early gene region which encodes a portion of the large T antigen. All cell lines examined contained the PY DNA Bum I fragment which contains most of the ...

The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-alpha/beta) and IFN-gamma signaling by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1). According to the proposed model, VP24 binding to members of the NPI-1 subfamily of karyopherin alpha (KPNalpha) nuclear localization signal receptors prevents their binding to PY-STAT1, thereby preventing PY-STAT...

Reactions of [8,8,8-(H)(PPh(3))(2)-9-(Py)-nido-8,7-RhSB(9)H(9)] (1), [1,1-(PPh(3))(2)-3-(Py)-closo-1,2-RhSB(9)H(8)] (2), and [1,1-(CO)(PPh(3))-3-(Py)-closo-1,2-RhSB(9)H(8)] (4), where Py = Pyridine, with HCl to give the Cl-ligated clusters, [8,8-(Cl)(PPh(3))-9-(Py)-nido-8,7-RhSB(9)H(9)] (3) and [8,8,8-(Cl)(CO)(PPh(3))-9-(Py)-nido-8,7-RhSB(9)H(8)] (5), have recently demonstrated the remarkable n...

The piano-stool Ru(II) arene complex [(η⁶-benz)Ru(bpm)(py)]²⁺ (benz = benzene, bpm = 2,2'-bipyrimidine, and py = pyridine), which is conventionally nonlabile (on a timescale and under conditions relevant for biological reactivity), can be activated by visible light to selectively photodissociate the monodentate ligand (py). In the present study, the aquation and binding of the photocontrolled r...

RmI, a circular chimera made of the polyomavirus (Py) genome with an insertion of mouse DNA (Ins), effectively undergoes intramolecular recombination in normal mouse cells, as indicated by the conversion of cloned RmI (RmIc) into unit-length Py DNA in transfected cultures. To follow the fate of the cellular component of RmI after recombination, the origin of simian virus 40 (SV40) DNA was inser...

We studied how similar postsynaptic responses are maintained in the face of interindividual variability in the number of presynaptic neurons. In the stomatogastric ganglion of the lobster, Homarus americanus, the pyloric (PY) neurons exist in variable numbers across animals. We show that each individual fiber of the stomach muscles innervated by PY neurons received synaptic input from all neuro...