The purpose of the study was to investigate the effects of shift work on the psychomotor and postural performance of night workers. The study included 20 polysomnography technicians working schedule of 12-h night shift by 36-h off. On the first day of protocol, the body mass and height were measured, and an actigraph was placed on the wrist of each participant. On the second day of protocol, sl...

OBJECTIVES To investigate the effect of modafinil 200 mg on the performance of a cohort of healthy male doctors after 1 night of supervised sleep deprivation. SUMMARY BACKGROUND DATA Sleep-deprived and fatigued doctors pose a safety risk to themselves and their patients. Yet, because of the around-the-clock nature of medical practice, doctors frequently care for patients after periods of exte...

BACKGROUND Driving a motor vehicle could be central to the functional autonomy of patients with psychiatric illnesses. For patients, a driver's license could mean independence, the ability to care for themselves, and the freedom to travel when they wish. However, both psychiatric disorders and psychiatric drug treatments can produce changes in perception, information processing and integration,...

benzodiazepine overdose is the most commonly encountered drug overdose in iran. it has been reported by many authors that flumazenil possesses highly specific antagonistic activity on central benzodiazepine receptors. we conducted a prospective study on 150 patients brought to the toxicology emergency ward in loghman-hakim hospital with benzodiazepine overdose to assess the efficacy of flumazen...

Stonier, P.D., A.C. Parrott, and 1. Hindmarch: Clobazam in combination with nomifensine (HOE 8476): effects on mood, sleep, and psychomotor Performance relating to car-driving ability. Drug Dev. Res. S1:047-055, 1982. The effects of three dose regimens of HOE 8476, a combination of nomifensine (25 mg) and clobazam (7.5 mg), placebo, and a combination of amitriptyline (25 mg) and chlordiazepoxid...

Physical exercise provides multiple benefits to an individual. However, the beneficial effect of exercise on psychomotor performance remains controversial. The present study was undertaken to determine the effect of aerobic exercise on auditory reaction time (ART) and visual reaction time (VRT). Fifty subjects were enrolled consisting of healthy subjects who were not exercising (n = 25; group I...

PURPOSE Our study aimed to profile the effect of fasting during the Ramadan month on cognitive function in a group of healthy Muslim athletes. METHODS Eighteen male athletes underwent computerized neuropsychological testing during (fasting) and after (non-fasting) Ramadan. Diet was standardized, and tests were performed at 0900h and 1600h to characterize potential time-of-day (TOD) interactio...

INTRODUCTION Because the multimodal antidepressant vortioxetine is likely to be coadministered with other central nervous system (CNS)-active drugs, potential drug-drug interactions warrant examination. OBJECTIVE These studies evaluated whether there are pharmacokinetic and/or pharmacodynamic interactions between vortioxetine and ethanol, diazepam, or lithium. METHODS This series of phase I...

Melatonin, a new addition to the armamentarium of anesthesiologist, has some unique properties that are highly desirable in routine peri-operative care. Available clinical data show that preoperative melatonin is as effective as benzodiazepines in reducing preoperative anxiety with minimal action on psychomotor performance and sleep wake cycle. It may be considered as a safe and effective alter...

3,4-Methylenedioxymethamphetamine (MDMA) is frequently consumed in association with alcohol. The effect of this combination in humans has not been previously investigated. Nine male healthy volunteers received single oral doses of 100 mg of MDMA plus 0.8 g/kg ethanol, 100 mg of MDMA, 0.8 g/kg of ethanol, and placebo in a double blind, double dummy, randomized crossover trial. Measurements inclu...