Die Anforderungsverfolgung bringt bei der Entwicklung von Produkt-Service-Systemen (PSS) zahlreiche Herausforderungen mit sich. Gründe hierfür sind komplexe Schnittstellen zwischen den Domänen Produkt-, Softwareund Dienstleistungsentwicklung, unterschiedliche Lebenszyklen und gegenseitige Beeinflussung einzelner Komponenten, ein hoher Grad an technischer Integration sowie eine kundenindividuell...

Presently marketed vaginal barrier agents are cytotoxic and damage the vaginal epithelium and natural vaginal flora with frequent use. Novel noncytotoxic agents are needed to protect women from sexually transmitted diseases. One candidate compound is a high-molecular-mass form of soluble poly(sodium 4-styrene sulfonate) (T-PSS). The antimicrobial activity of T-PSS was evaluated in primary cultu...

Objective To determine rates and primary discharge diagnoses of hospitalisation in a cohort of patients with incident primary Sjögren's syndrome (pSS) compared with the general population. Methods This was a retrospective population-based cohort study focused on Olmsted County, Minnesota. The pSS cohort consisted of patients with incident pSS in the 1976-2015 period and was compared with a co...

BACKGROUND Primary Sjögren's syndrome (pSS) is a systemic rheumatic disease in which gastrointestinal (GI) symptoms are common. Faecal calprotectin (FC) is a non-invasive biomarker that has been suggested to discriminate organic intestinal disease from functional disorders. The purpose of this study was to explore the usefulness of FC testing in patients with pSS. METHODS In total, 56 consecu...

OBJECTIVE To determine whether fibromyalgia (FM) is more common in patients with primary Sjögren's syndrome (pSS) who complain of fatigue. The association and prevalence of fatigue and FM was recorded in a group of patients with pSS and a control group of lupus patients, a subset of whom had secondary Sjögren's syndrome (sSS). METHODS 74 patients with pSS and 216 patients with lupus were asse...

Frequency offset estimation is an important module in the downlink synchronization process of orthogonal frequency division multiplexing (OFDM) system. Research on frequency synchronization of OFDM, a lowcomplexity and efficient method is proposed to evaluate frequency offset in this paper. In general, maximum likelihood (ML) based on cyclic prefix (CP) and primary synchronization signal (PSS) ...

OBJECTIVES Primary Sjögren's syndrome (pSS) shares clinical features and pathogenetic mechanisms with systemic lupus erythematosus (SLE). SLE is associated with an increased thromboembolic risk; however, it is unclear whether pSS patients are susceptible to thromboembolic diseases. In this study, we examined ex vivo blood clot formation (clot strength, rates of clot formation and lysis) in pSS ...

OBJECTIVE To evaluate the expression of interleukin 33 (IL-33) and its receptor in sera and salivary tissues of patients with primary Sjögren syndrome (pSS), and to investigate the association with clinical profiles. METHODS Serum IL-33 and soluble ST2 (sST2) of 55 patients with pSS and 48 controls were determined by ELISA and assessed for clinical correlation. The expression of IL-33/ST2 in ...

INTRODUCTION Psychiatric symptoms (PSs) are reported to occur frequently in people living with HIV and may be associated with specific antiretrovirals. We analyzed PSs observed with dolutegravir (DTG) and other frequently prescribed anchor drugs. METHODS Selected PSs (insomnia, anxiety, depression, and suicidality) occurring in HIV-positive patients during DTG treatment across 5 randomized cl...

Power system stabilizers (PSSs) must be capable of providing appropriate stabilization signals over abroad range of operating conditions and disturbances. The main idea of this paper is changing aclassic PSS (CPSS) to an adaptive PSS using genetic algorithm. This new genetic algorithm based onadaptive PSS (GAPSS) improves power system damping, considerably. The controller design issue isformula...