The steroid hormone aldosterone is secreted both in the setting of intravascular volume depletion and hyperkalemia, raising the question of how the kidney maximizes NaCl reabsorption in the former state while maximizing K(+) secretion in the latter. Mutations in WNK4 cause pseudohypoaldosteronism type II (PHAII), a disease featuring increased renal NaCl reabsorption and impaired K(+) secretion....

WNK kinases are a small group of unique serine/threonine protein kinases that are conserved among multicellular organisms. Mutations in WNK1-4 cause pseudohypoaldosteronism type II-a form of hypertension. WNKs have been linked to the STE20 kinases and ion carriers, but the underlying molecular mechanisms by which WNKs regulate cellular processes in whole animals are unknown. The Caenorhabditis ...

INTRODUCTIONPseudohypoaldosteronism is a heterogeneous group of disorders manifested by end-organ resistance to mineralocorticoids. We describe case recurrent salt wasting, hyperkalaemia and metabolic acidosis from this condition. RESULTSA 2.5-year-old girl was first presented us at day 8 life with poor feeding, lethargy in circulatory collapse requiring cardiopulmonary resuscitation. She not d...

The method of Darboux transformation, which is applied on cnoidal wave solutions of the sine-Gordon equation, gives solitons moving on a cnoidal wave background. Interesting characteristics of the solution, i.e., the velocity of solitons and the shift of crests of cnoidal waves along a soliton, are calculated. Solutions are classified into three types (Type-1A, Type-1B, Type-2) according to the...

We study sine-Gordon kink diffusion at finite temperature in the overdamped limit. By means of a general perturbative approach, we calculate the first- and second-order (in temperature) contributions to the diffusion coefficient. We compare our analytical predictions with numerical simulations. The good agreement allows us to conclude that, up to temperatures where kink-antikink nucleation proc...

In Phys. Rev. B 42, 2290 (1990) we used a rigorous projection operator collective variable formalism for nonlinear Klein-Gordon equations to prove the continuum sine-Gordon (SG) equation has a long lived quasimode whose frequency is in the continuum just above the lower phonon band edge with a lifetime . We confirmed the analytic calculations by simulations which agreed very closely with the an...

Flowers for Algernon is a novel written in 1966 by Daniel Keyes. Since its publication, it has received significant critical acclaim, earning a Nebula science-fiction award, and was also adapted into a feature film. Set in the 1960s, the novel follows the story of Charlie Gordon, an intellectually disabled man who lives a simple but happy life working a cleaning job at a local bakery. Charlie's...

plicity, and experimental accessibility compared to CNS synapses. At fly neuromuscular junctions, presynaptic terminals consist of a series of branches, decorated with boutons containing active zones, whereas in worm, presynaptic terminals are arrayed like beads on a string. Qiang Chang and Rita J. Balice-Gordon* Department of Neuroscience University of Pennsylvania School of Medicine Philadelp...