نتایج جستجو برای: proteomic

تعداد نتایج: 23982  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Yan Ma Zhenyu Ding Yong Qian Xianglin Shi Vince Castranova E James Harner Lan Guo

PURPOSE Accurate prediction of an individual patient's drug response is an important prerequisite of personalized medicine. Recent pharmacogenomics research in chemosensitivity prediction has studied the gene-drug correlation based on transcriptional profiling. However, proteomic profiling will more directly solve the current functional and pharmacologic problems. We sought to determine whether...

2013
Elizabeth V. Nguyen Sina A. Gharib Steven J. Palazzo Yu-hua Chow David R. Goodlett Lynn M. Schnapp

RATIONALE Ventilator-associated pneumonia (VAP) is a common complication in patients with acute lung injury (ALI) and can lead to increased morbidity and mortality. Identifying protein profiles specific to VAP in bronchoalveolar lavage fluid (BALF) may aid in earlier diagnosis, elucidate mechanisms of disease, and identify putative targets for therapeutic intervention. METHODS BALF was obtain...

Journal: :The Journal of antimicrobial chemotherapy 2014
Sang-Yeop Lee Sung Ho Yun Yeol Gyun Lee Chi-Won Choi Sun-Hee Leem Edmond Changkyun Park Gun-Hwa Kim Je Chul Lee Seung Il Kim

OBJECTIVES To determine the genomic sequence of extensively drug-resistant Acinetobacter baumannii DU202 and to perform proteomic characterization of antibiotic resistance in this strain using genome data. METHODS The genome sequence of A. baumannii DU202 was determined using the Hi-Seq 2000 system and comparative analysis was performed to determine the unique characteristics of A. baumannii ...

Journal: :Lancet 2002
Emanuel F Petricoin Ali M Ardekani Ben A Hitt Peter J Levine Vincent A Fusaro Seth M Steinberg Gordon B Mills Charles Simone David A Fishman Elise C Kohn Lance A Liotta

BACKGROUND New technologies for the detection of early-stage ovarian cancer are urgently needed. Pathological changes within an organ might be reflected in proteomic patterns in serum. We developed a bioinformatics tool and used it to identify proteomic patterns in serum that distinguish neoplastic from non-neoplastic disease within the ovary. METHODS Proteomic spectra were generated by mass ...

2015
Kelly L. Stauch Phillip R. Purnell Lance M. Villeneuve Howard S. Fox

Mitochondria are dynamic organelles critical for many cellular processes, including energy generation. Thus, mitochondrial dysfunction likely plays a role in the observed alterations in brain glucose metabolism during aging. Despite implications of mitochondrial alterations during brain aging, comprehensive quantitative proteomic studies remain limited. Therefore, to characterize the global age...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Noura S Abul-Husn Lakshmi A Devi

Proteomic analyses of brain tissues are becoming an integral component of neuroscientific research. In particular, the essential role of the synapse in neurotransmission and plasticity has brought about extensive efforts to identify its protein constituents. Recent studies have used a combination of subcellular fractionation and proteomic techniques to identify proteins associated with differen...

Journal: :Molecular & cellular proteomics : MCP 2016
Boris Bogdanow Henrik Zauber Matthias Selbach

The principle of shotgun proteomics is to use peptide mass spectra in order to identify corresponding sequences in a protein database. The quality of peptide and protein identification and quantification critically depends on the sensitivity and specificity of this assignment process. Many peptides in proteomic samples carry biochemical modifications, and a large fraction of unassigned spectra ...

Journal: :Molecular & cellular proteomics : MCP 2008
Suresh Mathivanan Akhilesh Pandey

Clinical proteomics is an emerging field that deals with the use of proteomic technologies for medical applications. With a major objective of identifying proteins involved in pathological processes and as potential biomarkers, this field is already gaining momentum. Consequently, clinical proteomics data are being generated at a rapid pace, although mechanisms of sharing such data with the bio...

Journal: :Fertility and sterility 2012
Nicolas Galazis Olalekan Olaleye Zeina Haoula Robert Layfield William Atiomo

OBJECTIVE To review and identify possible biomarkers for ovarian cancer (OC) in women with polycystic ovary syndrome (PCOS). DESIGN Systematic literature searches of MEDLINE, EMBASE, and Cochrane using the search terms "proteomics," "proteomic," and "ovarian cancer" or "ovarian carcinoma." Proteomic biomarkers for OC were then integrated with an updated previously published database of all pr...

Journal: :Proteomics. Clinical applications 2009
Yuan Tian Aik-Choon Tan Xiaer Sun Matthew T Olson Zhi Xie Natini Jinawath Daniel W Chan Ie-Ming Shih Zhen Zhang Hui Zhang

Paclitaxel has been widely used as an anti-mitotic agent in chemotherapy for a variety of cancers and adds substantial efficacy as the first-line chemotherapeutic regimen for ovarian cancers. However, the frequent occurrence of paclitaxel resistance limits its function in long-term management. Despite abundant clinical and cellular demonstration of paclitaxel resistant tumors, the molecular mec...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید