growth defect in Saccharomyces cerevisiae. phosphatase gene (PTC1) cause a synthetic gene (PTP2) and a protein serine/threonine Mutations in a protein tyrosine phosphatase

PTP20, also known as HSCF/protein-tyrosine phosphatase K1/fetal liver phosphatase 1/brain-derived phosphatase 1, is a cytosolic protein-tyrosine phosphatase with currently unknown biological relevance. We have identified that the nonreceptor protein-tyrosine kinase Tec-phosphorylated PTP20 on tyrosines and co-immunoprecipitated with the phosphatase in a phosphotyrosine-dependent manner. The int...

In hematopoietic cells, the protein tyrosine phosphatase PTP1C appears to play a central role in the termination of signalling by receptors that activate protein tyrosine kinases.