In atrial myocytes, an initial exposure to isoproterenol (ISO) acts via cAMP to mediate a subsequent acetylcholine (ACh)-induced activation of ATP-sensitive K(+) current (I(K,ATP)). In addition, beta-adrenergic receptor (beta-AR) stimulation activates nitric oxide (NO) release. The present study determined whether the conditioning effect of beta-AR stimulation acts via beta(1)- and/or beta(2)-A...

1. The aim of this study was to assess the effects of treatment with isoproterenol (ISO, 0.3 mg kg-1 day-1, s.c.) for 7 days on the vascular reactivity of rat-isolated aortic rings. Additionally, potential mechanisms underlying the changes that involved the endothelial modulation of contractility were investigated. 2. Treatment with ISO induced cardiac hypertrophy without changes in haemodynami...

There are only a few protein repair enzymes known. One of them, Protein Iso-Aspartate Methyltransferases (PIMT), also known as Carboxyl (PCMT), is responsible for converting (abnormal amino acid residues) to Aspartate (normal residues). PCMT an enzyme found in wide range living organisms. In the present study, sequence PIMT Shigella flexneri was retrieved and 3D structure predicted. Further, it...

three groups of 11 new zealand white (nzw) rabbit does, each were reared from 12 weeks of age on iso-energetic diets containing 16, 14 or 12% crude protein (cp) were used to study influences on productive performance, digestibility, some carcass traits, haematological, biochemical and hormonal parameters of rabbit does. the results showed rabbits fed on 16% protein diet had heavier body weights...

The hypothesis that cellular protein carboxyl-methylation reactions recognize altered aspartyl residues as part of a protein repair pathway has been tested in an in vitro system using tetragastrin (Trp-Met-Asp-Phe-NH2) as a model sequence. The L-isoaspartyl form of tetragastrin, where the phenylalanine residue is linked to the side-chain carboxyl group of the aspartate residue ([iso-Asp3]tetrag...

Software development in a small development team is a challenge, as people have to fulfill several roles, which in larger groups would have separate, dedicated people for the work. To help small development teams to organize their activities, ISO/IEC standardization body has developed the standard ISO/IEC 29110, Lifecycle profiles for Very Small Entities. Our study focuses on the application of...

In this paper we report on ongoing verification and validation work within the MULTIDOC project. This project is situated in the field of multilingual automotive product documentation. One central task is the evaluation of existing off-the-shelf and research based language technology (LT) products and components for the purpose of supporting or even reorganising the documentation production cha...

Sublingual nitroglycerin (TNG) has been introduced as a promising provocative agent for tilt table testing, but it has not been compared directly with the standard isoproterenol (ISO) infusion test previously. We tried to assess the diagnostic value and safety of TNG tilt testing as compared with ISO infusion in patients with unexplained syncope. TNG and ISO tilt tests were performed in tw...

in a completely randomized design, the effect of four iso-protein and iso-caloric diets containing different levels (0, 8, 16 and 24%) of processed broiler litter was studied on the fattening performance of 60 holstein male calves (with initial weight of 309±9kg and about 8-9 month age) for a period of 200 days. at the end of the experiment, all animals were slaughtered and then the carcasses, ...

Developing high-quality asynchronous store-and-forward telemedicine systems (ASFTSs) remains a challenge. However, there is no accepted understanding as to what are the important quality characteristics for this type of software system and/or what defines a mature software process for producing high-quality ASTFSs. Through adopting a multi-step research methodology, we define a quality model fo...