background: prostate cancer has been reported as the second leading cause of cancer death and the most common cancer diagnosed in men. since health belief model (hbm) has been intensively used for assessing health beliefs associated with cancer screening behaviors, we aimed to investigate the level of knowledge and health beliefs about prostate cancer screening among retired men. methods: in th...

perforin(p) is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory  cytokines and stored in t lymphocyte , nk cells and nkt cells are released upon activation. perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens , alloantigens and particularly different tumors.the purpose of this study was to de...

recently, specific attention has been paid to aptamers, short dna or rna, as a tool for cancer diagnosis and therapy. in the present study mcs nanogels were prepared by myristate: chitosan at 1:9 ratio and were characterized by several techniques. a selected ssdna aptamer(apt) capable of detecting lncap cells was linked to myristilated chitosan nanogels (apt-mcs) by glutaraldehyde and loaded wi...

background: to determine a cut-off point of tpsa and psad to prevent unnecessary invasive cancer-diagnosing tests in the community. methods: this study was performed on 688 consecutive patients referred to our center due to prostatism, suspicious lesions on digital rectal examination and/or elevated serum psa levels. all patients underwent transrectal ultrasound guided biopsies and obtained psa...

background: prostate cancer after lung cancer is the second cause of cancer-associated death in men. in recent years, targeted therapy of cancer has attracted researchers attention. the targeted therapy lead to decrease in side effects of drugs. studies have indicated that targeting peptides for cancer cells represent valuable tools for diagnostic and therapeutic. recently, phage display peptid...

introduction: aim of this study was to assess the association between prostate calcification in transrectalultrasound (trus) and sono- guided needle biopsy in prostate cancer (pca). methods: a cross-sectional study was performed on patients referred to imam khomeini hospital between 2005 and 2011 who underwent trus biopsy due to increased psa or abnormal dre. the serum levels of psa, prostate v...

Background: According to the EAU guidelines, a life expectancy of more than 10 years is considered an important factor in the treatment of prostate cancer. The Charlson score is used to predict mortality based on comorbidies.The purpose of this study was to investigate the relationship between age, Charlson score and outcome in patients with cT3a prostate cancer. Materials and Methods: Between ...

background: androgen receptors (ar) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. current drugs cannot inhibit the activity of these receptors very well. establishment of appropriate animal models is essential for discovery of new drugs of target therapy in hormone dependent prostate cancer. materials and methods: standard prostatic ...

background : a transrectal ultrasound-guided prostate biopsy is currently the gold standard procedure to detect prostatic adenocarcinoma. there is little information on the clinical utility of this technique for the detection of prostate adenocarcinoma in men with suspected prostate cancer in pakistan. this study seeks to determine the frequency of prostatic adenocarcinoma by using a transrecta...