The role of the tachykinin neurokinin (NK)(2) receptors on rabbit distal colon propulsion was investigated by using two selective NK(2)-receptor antagonists, MEN-10627 and SR-48968. Experiments on colonic circular muscle strips showed that contractile responses to [beta-Ala(8)]NKA-(4-10) (1 nM-1 microM), a selective NK(2)-receptor agonist, were competitively antagonized by MEN-10627 (1-100 nM),...

Unavailability of a ship propulsion system under aging effects and proper maintenance is estimated using GO‐FLOW. GO‐FLOW is an effective software tool for the unavailability analysis of complex systems. Aging effects are incorporated into GO‐FLOW using a time‐dependent technique and assuming a linear aging model. The results show that the aging effects and improper maint...

BACKGROUND The hand pattern used during manual wheelchair propulsion (i.e., full-cycle hand path) can provide insight into an individual's propulsion technique. However, previous analyses of hand patterns have been limited by their focus on a single propulsion condition and reliance on subjective qualitative characterization methods. The purpose of this study was to develop a set of objective q...

Propulsion airframe integration design and analysis has many challenges as we move into the 21 century. Along with the conventional challenges of integrating a propulsion system on an aircraft, new technologies and new business drivers dictate innovative approaches to the design process be developed and applied. On the technical side, new innovations in jet noise suppression and new aircraft co...

Designing and developing new aerospace propulsion systems is time-consuming and expensive. Computational simulation is a promising means for alleviating this cost, but requires a flexible software simulation system capable of integrating advanced multidisciplinary and multifidelity analysis methods, dynamically constructing arbitrary simulation models, and distributing computationally complex t...

PURPOSE: This study was measured the differences in the flexor and extensor muscle activities of the elbow joints based on the tire pressure of wheelchairs during propulsion, investigating the optimal tire pressure for improving occupants’ propulsion and avoiding related injury. METHODS: Ten healthy volunteers (10 men aged 23.1 ± 1.9 years, weight: 67.9 ± 3.4 kg, height: 175.1 ± 2.7 cm) took pa...

Hybrid electric aircraft concepts are high in future aviation agenda to enabling reduced fuel consumption and emissions. However, the additional weight of introduced battery electrical components sizing cascading effects will impact mission analysis performance. Therefore, potential benefit adopting hybrid highly depend on applied energy management strategy (EMS). This paper presents a three-la...

The aim of the study was to investigate if pushrim kinetics could be used as markers of glenohumeral joint demand during manual wheelchair accessibility activities; demonstrating a method of biomechanical analysis that could be used away from the laboratory. Propulsion forces, trunk and upper limb kinematics and surface electromyography were recorded during four propulsion tasks (level, 2.5% cr...