EDITOR: Propofol infusion syndrome (PRIS) is a rare and often fatal disease associated with propofol sedation at doses of more than 5 mg kg h for more than 48 h. PRIS is characterized by lipaemic plasma, fatty liver enlargement, metabolic acidosis, rhabdomyolysis or myoglobinuria, cardiac arrhythmia and acute bradycardia progressing to asystole. The syndrome usually occurs in patients with cent...

Differences in the pharmacokinetics of propofol between male and female patients during and after continuous infusion have not been described in detail in patients aged 65 yr and older. To increase our insight into the pharmacokinetics of propofol in this patient population and to obtain pharmacokinetic parameters applicable in target controlled infusion (TCI), the pharmacokinetics of propofol ...

Propofol has been established as a reliable method for sedation in flexible bronchoscopy. There are no data comparing propofol administered as intravenous boluses versus continuous infusion. 702 consecutive patients undergoing flexible bronchoscopy were randomly allocated to receive intravenous propofol using either an intermittent bolus technique or a continuous infusion. The primary end-point...

SEDATION IN INTENSIVE CARE PAtients is assumed to reduce discomfort from care interventions, increase tolerance of mechanical ventilation, prevent accidental removal of instrumentation, and reduce metabolic demands during cardiovascular and respiratory instability. Long-term sedation may have serious adverse effects, such as prolonged mechanical ventilation, coma, delirium, delusional memories ...

We have compared the haemodynamic effects of a sedative dose of propofol with placebo (vehicle of propofol) in a randomized, double-blind study in 20 patients immediately after coronary artery bypass grafting (CABG). During a continuous infusion of a mixture of fentanyl and pancuronium, each patient was given in a crossover design, a loading dose of propofol 0.5 mg kg-1 and vehicle over 5 min f...

BACKGROUND Propofol is commonly used to anesthetize children undergoing esophagogastroduodenoscopy. Opioids are often used in combination with propofol to provide total intravenous anesthesia. Because both propofol and remifentanil are associated with rapid onset and offset, the combination of these two drugs may be particularly useful for procedures of short duration, including esophagogastrod...

objective: to evaluate, the efficacy of sub hypnotic doses of midazolam and propofol, in prophylactic control of postoperative nausea and vomiting, in parturients undergoing elective cesarean section under spinal anesthesia. materials and methods: in a double-blind, placebo-controlled, randomized trial, 114 asa physical status i-ii parturient undergoing elective cesarean section under spinal an...