It has been known for many years that cooperative interactions between oncogenes (e.g. RAS, MYC, BCL2) can fuel cancer growth (1-5), but the restricted druggability of many of those interacting cancer genes has hampered translation of combined targeting to medical cancer therapy. The identification and characterization of cooperative cancer signaling pathways amenable to medical therapy is ther...

The absence of effective therapies for hormone refractory prostate cancer establishes the need to develop novel therapeutic modality, such as a gene therapy, that can be applied either separately or in conjunction with current treatment modalities for the treatment of advanced prostate cancer. About 80 protocols for prostate cancer gene therapy have been practiced since 1994. The gene therapy m...

the main purpose of this study was to explore factors influencing immigration from rural to urban areas in varkaneh , a famous village and tourist destination located in western part of iran- hamedan. a questionnaire was designed and validated by a panel of experts from extension education dept. of bu-ali sina university and hamadan jihad of agriculture. its reliability was secured by cronbach’...

background: healthy lifestyle is a major strategy to promote current and subsequent health status. the aim of this study was to assess the status of health‑promoting the lifestyle and its determinants among students. methods: a stratified random sample of 500 students in a university in the city of sabzevar, iran participated in this cross‑sectional study. health‑promoting lifestyle was measure...

abstract plant- growth promoting rhizobacteria enhance plant growth and yield directly and or indirectly. a factorial experiment was conducted in greenhouse to determine the efficacy of four strains of fluorescent pseudomonas on wheat yield and yield component under saline conditions. the experiment was carried out with the following treatments (non –inoculation control and inoculation with p.f...

conclusions: focusing on successful aging and adopting hpbs can prevent and decrease aging problems which in turn decreases the financial burden and related costs. this is especially important for the policy and decision makers of the health systems. results: the mean age of the participants in this study was 65.9 ± 3.6 (range 60-73). results showed a statistically significant difference betwee...

NYC RECOVERS, an alliance of organizations concerned with New York City's social and emotional recovery post-9/11, was formed to meet the need to rebuild social bonds strained or ruptured by the trauma to the regional system caused by the destruction of the Twin Towers. NYC RECOVERS, with minimal funding, was able to create a network of 1000 organizations spanning the five boroughs, carrying ou...

This paper analyzes the evolution of policies for technology catch-up through three periods: the import substitution period, the (augmented) Washington Consensus period and the post-Washington period. We analyze the dominant policy models and practices in each of these periods as co-evolving with the dominant academic ideas, thereby changing the conditions for catching up. We develop several di...

BACKGROUND Health outcome trials have provided strong evidence that participating in regular physical activity can improve the quality of life and health of post-treatment breast cancer survivors. Focus is now needed on how to promote changes in physical activity behaviour among this group. PURPOSE This systematic review examines the efficacy of behavioural interventions for promoting physica...

BACKGROUND Profound cellular and biochemical remodeling processes occur in the brain following an ischemic stroke, raising the possibility that we may be able to promote neurological recovery by harnessing the brain's endogenous recovery processes with pharmacological or cell-based therapies. There is a compelling body of evidence that cerebral plasticity and neurological recovery can be stimul...