BACKGROUND The aim of this paper is to evaluate the efficacy and safety of DLBS3233, a novel bioactive fraction derived from Cinnamomum burmanii and Lagerstroemia speciosa, in improving insulin resistance and preserving β-cell performance in patients with impaired glucose tolerance (IGT). PATIENTS AND METHODS Eighty adult subjects with IGT, defined as 2-hour postprandial glucose level of 140-...

Motivated by the data from Super-Kamiokande and elsewhere indicating oscillations of atmospheric and solar neutrinos, we study charged-lepton-flavour violation, in particular the radiative decays μ → eγ and τ → μγ, but also commenting on μ → 3e and τ → 3μ/e decays, as well as μ → e conversion on nuclei. We first show how the renormalization group may be used to calculate flavour-violating soft ...

Opposing the pre-dominant turn-wise statistics of acoustic LowLevel-Descriptors followed by static classification we re-investigate dynamic modeling directly on the frame-level in speech-based emotion recognition. This seems beneficial, as it is well known that important information on temporal sub-turn-layers exists. And, most promisingly, we integrate this frame-level information within a sta...

Overall, doxorubicine-congestive heart failure (CHF) (male Wistar rats and NMRI mice; 6 challenges with doxorubicine (2.5 mg/kg, i.p.) throughout 15 days and then a 4-week-rest period) is consistently deteriorating throughout next 14 days, if not reversed or ameliorated by therapy (/kg per day): a stable gastric pentadecapeptide BPC157 (GEPPPGKPADDAGLV, MW 1419, promisingly studied for inflamma...

Seamless computing and service sharing in community networks (CNs) have gained momentum due to the emerging technology of community network micro-clouds (CNMCs). However, deploying and running services in CNMCs confront enormous challenges to cope with, such as the dynamic nature of micro-clouds, limited capacity of nodes and links, asymmetric quality of wireless links, geographic singularity b...

UNLABELLED Gold nanoparticles (GNPs) with near infrared (NIR) plasmon resonance have been promisingly used in photothermal cancer therapy as a less invasive treatment. Recombinant Protein-G (ProG) was PEGylated to act as a cofactor to immobilize immunoglobulins (IgGs) on GNPs by the Fc region, resulting in optimal orientation of IgGs for efficient cancer targeting. In-vitro studies showed that ...

Rapid loss of global biodiversity has motivated a number of recent experiments that seek to understand how species richness affects ecosystem functioning. In the first round of studies, researchers have formed local communities differing in richness by selecting species at random from an experimental species pool, which is a subset of the 'regional' collection of species. Often, the effects of ...

High-throughput post-genomic studies are now routinely and promisingly investigated in biological and biomedical research. The main statistical approach to select genes differentially expressed between two groups is to apply a t-test, which is subject of criticism in the literature. Numerous alternatives have been developed based on different and innovative variance modeling strategies. However...

In this paper, we present an effective and efficient diagnosis system using fuzzy k-nearest neighbor (FKNN) for Parkinson’s disease (PD) diagnosis. The proposed FKNN-based system is compared with the support vector machines (SVM) based approaches. In order to further improve the diagnosis accuracy for detection of PD, the principle component analysis was employed to construct the most discrimin...

The effect of mesenchymal stem cell (MSCs)-based therapy on treating acute myocardial infarction (MI) is limited due to poor engraftment and limited regenerative potential. Here we engineered MSCs with integrin-linked kinase (ILK), a pleiotropic protein critically regulating cell survival, proliferation, differentiation, and angiogenesis. We firstly combined ferumoxytol with poly-L-lysine (PLL)...