the smooth muscle of the gastrointestinal (GI) tract of dog and is potentially useful as a GI prokinetic agent. In an effort to extend the SARof the motilides, we decided to determine the effect of C-12 deoxygenation of 2 on both antibacterial and prokinetic activities. The deoxy congener with the natural (R) configuration at C-12 4 is synthetically accessible3) from erythromycin B 3, but in or...

This study was undertaken to investigate the prokinetic activity of Unani herbomineral formulation (Dolabi) in streptozotocin induced diabetic rats and its in vitro antioxidant activity. Rat model of diabetes was established by intraperitoneal injection of streptozotocin (55 mg/kg, i.p). Rats were divided into three groups: Normal control, diabetic control and treatment groups. After two weeks ...

Background Herbal formula Modified Buzhong-Yiqi-Tang (MBYT) has been widely used for the treatment of functional constipation in East Asia, but its efficacy and safety are unclear. Methods The study was to evaluate the efficacy and safety of MBYT for adult patients with functional constipation. Randomized clinical trials were selected according to predefined inclusion and exclusion criteria. ...

Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a-d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT(4) agonist and 5-HT(3) antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders in adults, children, and adolescents. This paper reviews etiology pathogenesis IBS, particularly its subtypes, postinfectious associated with a prior acute intestinal infection. The authors discuss risk factors, diagnosis, treatment for IBS describe diagnostic search therapeutic algorithm child. Treat...

This article is linked to Kuo et al and Camilleri & papers. To view these articles, visit https://doi.org/10.1111/apt.16451 https://doi.org/10.1111/apt.16475 There an urgent need for safe effective pharmacotherapy in gastroparesis, a debilitating condition estimated affect 13.8 per 100 000 persons the United Kingdom.1 Adults with gastroparesis are recognised suffer from repeated hospitalisation...